BRENDA - Enzyme Database show
show all sequences of 2.1.1.114

Restoring de novo coenzyme Q biosynthesis in Caenorhabditis elegans coq-3 mutants yields profound rescue compared to exogenous coenzyme Q supplementation

Gomez, F.; Saiki, R.; Chin, R.; Srinivasan, C.; Clarke, C.F.; Gene 506, 106-116 (2012)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expressed in an Escherichia coli ubiG mutant
Caenorhabditis elegans
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate
Caenorhabditis elegans
-
S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate
-
-
?
S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate
Caenorhabditis elegans N2
-
S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Caenorhabditis elegans
-
-
-
Caenorhabditis elegans N2
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate
-
733930
Caenorhabditis elegans
S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate
-
-
-
?
S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate
-
733930
Caenorhabditis elegans N2
S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate
-
-
-
?
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in an Escherichia coli ubiG mutant
Caenorhabditis elegans
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate
Caenorhabditis elegans
-
S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate
-
-
?
S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate
Caenorhabditis elegans N2
-
S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate
-
733930
Caenorhabditis elegans
S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate
-
-
-
?
S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate
-
733930
Caenorhabditis elegans N2
S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate
-
-
-
?
General Information
General Information
Commentary
Organism
malfunction
a deletion mutant shows arrested development and is sterile when fed the coenzyme Q-deficient Escherichia coli strain GD1; deletion mutants are sterile and show arrested development when fed the coenzyme Q-deficient Escherichia coli strain GD1
Caenorhabditis elegans
General Information (protein specific)
General Information
Commentary
Organism
malfunction
a deletion mutant shows arrested development and is sterile when fed the coenzyme Q-deficient Escherichia coli strain GD1; deletion mutants are sterile and show arrested development when fed the coenzyme Q-deficient Escherichia coli strain GD1
Caenorhabditis elegans
Other publictions for EC 2.1.1.114
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
733306
Zhu
Structural and biochemical stu ...
Escherichia coli, Homo sapiens
Biochem. J.
470
105-114
2015
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2
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733930
Gomez
Restoring de novo coenzyme Q b ...
Caenorhabditis elegans, Caenorhabditis elegans N2
Gene
506
106-116
2012
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1
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18
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1
1
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704413
Marbois
Lee, P.T.; Strahan, J.; Shephe ...
Saccharomyces cerevisiae
J. Biol. Chem.
280
20231-20238
2005
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1
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485141
Jonassen
Isolation and functional expre ...
Homo sapiens
J. Biol. Chem.
275
12381-12387
2000
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-
1
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1
1
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1
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1
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485140
Poon
Yeast and rat Coq3 and Escheri ...
Rattus norvegicus, Saccharomyces cerevisiae
J. Biol. Chem.
274
21665-21672
1999
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1
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2
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8
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485139
Avelange-Macheral
Cloning and functional express ...
Arabidopsis thaliana
Plant J.
14
203-213
1998
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703840
Marbois
Cloning of a rat cDNA encoding ...
Rattus norvegicus
Gene
138
213-217
1994
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1
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4
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485138
Clarke
Ubiquinone biosynthesis in Sac ...
Saccharomyces cerevisiae
J. Biol. Chem.
266
16636-16644
1991
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1
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1
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4
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