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Literature summary for 2.1.1.114 extracted from

  • Jonassen, T.; Clarke, C.F.
    Isolation and functional expression of human COQ3, a gene encoding a methyltransferase required for ubiquinone biosynthesis (2000), J. Biol. Chem., 275, 12381-12387.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
when expressed in multicopy, the human construct rescues the growth of a yeast coq3 null mutant on a nonfermentable carbon source and restores coenzyme Q biosynthesis, although at lower levels than that of wild type yeast Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40998
-
x * 40998, calculated from sequence Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + 5-all-trans-decaprenyl-3,4-dihydroxybenzoate Homo sapiens the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-10, 1. the methylation of 5-all-trans-decaprenyl-3,4-dihydroxybenzoate and 2. the methylation of 3-demethylubiquinol-10 (this reaction is classified as EC 2.1.1.64) S-adenosyl-L-homocysteine + 5-all-trans-decaprenyl-4-hydroxy-3-methoxybenzoate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NZJ6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information wide substrate specificity. The enzyme methylates both eukaryotic substrates demethylubiquinol-3 (this activity is classified as EC 2.1.1.64) and 3,4-dihydroxy-5-farnesylbenzoic acid and the distinct prokaryotic substrate 3-((2E,6E)-farnesyl)benzene-1,2-diol Homo sapiens ?
-
?
S-adenosyl-L-methionine + 3,4-dihydroxy-5-(2E,6E)-farnesylbenzoate in vitro assay Homo sapiens S-adenosyl-L-homocysteine + 5-(2E,6E)-farnesyl-4-hydroxy-3-methoxybenzoate
-
?
S-adenosyl-L-methionine + 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate is an intermediate in biosynthesis of ubiquinone-6 in Saccharomyces cerevisiae (that is methylated by the yeast enzyme CoQ3 to 4-hydroxy-3-methoxy-5-hexaprenylbenzoate). When expressed in multicopy, the human construct rescues the growth of a yeast coq3 null mutant on a nonfermentable carbon source and restores coenzyme Q biosynthesis, although at lower levels than that of wild type yeast Homo sapiens S-adenosyl-L-homocysteine + 5-all-trans-hexaprenyl-4-hydroxy-3-methoxybenzoate
-
?
S-adenosyl-L-methionine + 5-all-trans-decaprenyl-3,4-dihydroxybenzoate the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-10, 1. the methylation of 5-all-trans-decaprenyl-3,4-dihydroxybenzoate and 2. the methylation of 3-demethylubiquinol-10 (this reaction is classified as EC 2.1.1.64) Homo sapiens S-adenosyl-L-homocysteine + 5-all-trans-decaprenyl-4-hydroxy-3-methoxybenzoate
-
?

Subunits

Subunits Comment Organism
? x * 40998, calculated from sequence Homo sapiens

Synonyms

Synonyms Comment Organism
COQ3
-
Homo sapiens
Coq3 O-methyltransferase
-
Homo sapiens