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Literature summary for 2.1.1.101 extracted from

  • Kim, E.; Song, M.; Kim, M.; Beom, J.; Lee, E.; Kim, D.; Nam, S.; Yoon, Y.
    Characterization of the two methylation steps involved in the biosynthesis of mycinose in tylosin (2016), J. Nat. Prod., 79, 2014-2021 .
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Streptomyces fradiae Q9S4D5
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + demethyllactenocin
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Streptomyces fradiae S-adenosyl-L-homocysteine + 2'''-O-demethyldesmycosin
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S-adenosyl-L-methionine + demethylmacrocin
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Streptomyces fradiae S-adenosyl-L-homocysteine + 2'''-O-demethyltylosin
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S-adenosyl-L-methionine + lactenocin
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Streptomyces fradiae S-adenosyl-L-homocysteine + desmycosin
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?

General Information

General Information Comment Organism
metabolism TylF-catalyzed C3'''-O-methylation of the 6-deoxy-D-allose moiety can precede the C2'''-O-methylation catalyzed by TylE when TylF is overexpressed in the absence of TylE. TylF has a preference for macrocin/lactenocin over demethylmacrocin/demethyllactenocin Streptomyces fradiae