Inhibitors | Comment | Organism | Structure |
---|---|---|---|
adenosine | plus homocysteine | Bos taurus | |
N-acetyl-S-geranylgeranyl-L-cysteine | - |
Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + (RhoAA) C-terminal S-farnesyl-L-cysteine | Bos taurus | the enzyme modulates endothelial monolayer per meability by altering RhoA carboxyl methylation and activation, thus changing the organization of intercellular junctions. Carboxy methylation of RhoA may modulate endothelial barrier function | S-adenosyl-L-homocysteine + (RhoA) C-terminal S-farnesyl-L-cysteine methyl ester | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pulmonary artery endothelial cell | stably overexpressing isoprenylcysteine carboxyl methyltransferase/GFP cDNA | Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + (RhoAA) C-terminal S-farnesyl-L-cysteine | - |
Bos taurus | S-adenosyl-L-homocysteine + (RhoA) C-terminal S-farnesyl-L-cysteine methyl ester | - |
? | |
S-adenosyl-L-methionine + (RhoAA) C-terminal S-farnesyl-L-cysteine | the enzyme modulates endothelial monolayer per meability by altering RhoA carboxyl methylation and activation, thus changing the organization of intercellular junctions. Carboxy methylation of RhoA may modulate endothelial barrier function | Bos taurus | S-adenosyl-L-homocysteine + (RhoA) C-terminal S-farnesyl-L-cysteine methyl ester | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Icmt | - |
Bos taurus |
isoprenylcysteine carboxyl methyltransferase | - |
Bos taurus |