Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.100 extracted from

  • Perez-Sala, D.; Gilbert, B.A.; Tan, E.W.; Rando, R.R.
    Prenylated protein methyltransferases do not distinguish between farnesylated and geranylgeranylated substrates (1992), Biochem. J., 284, 835-840.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.100

Inhibitors

Inhibitors Comment Organism Structure
N-acetyl-S-(E,E)-farnesyl-L-cysteine
-
 Bos taurus
N-acetyl-S-(E,E)-geranylgeranyl-L-cysteine
-
 Bos taurus
N-acetyl-S-geranylgeranyl-L-cysteine inhibition of N-acetyl-S-farnesyl-L-cysteine methylation Bos taurus
S-(Geranylgeranyl-2-thio)acetic acid
-
 Bos taurus
S-Farnesylthioacetic acid
-
 Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0192
-
 N-acetyl-S-geranylgeranyl-L-cysteine
-
 Bos taurus
0.0223
-
 N-acetyl-S-farnesyl-L-cysteine
-
 Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
retina
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + N-acetyl-S-geranylgeranyl-L-cysteine
-
 Bos taurus S-adenosyl-L-homocysteine + N-acetyl-S-geranylgeranyl-L-cysteine methyl ester
-
 ?
S-adenosylmethionine + N-acetyl-S-(E,E)-farnesyl-L-cysteine
-
 Bos taurus S-adenosylhomocysteine + N-acetyl-S-(E,E)-farnesyl-L-cysteine methyl ester
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0023
-
 N-acetyl-S-(E,E)-geranylgeranyl-L-cysteine competitive vs. N-acetyl-S-(E,E)-farnesyl-L-cysteine Bos taurus
0.0026
-
 N-acetyl-S-(E,E)-farnesyl-L-cysteine competitive vs. N-acetyl-S-(E,E)-geranylgeranyl-L-cysteine Bos taurus
0.0039
-
 S-(Geranylgeranyl-2-thio)acetic acid competitive vs. N-acetyl-S-(E,E)-farnesyl-L-cysteine Bos taurus
0.0046
-
 S-Farnesylthioacetic acid competitive vs. N-acetyl-S-(E,E)-farnesyl-L-cysteine Bos taurus