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Literature summary for 2.1.1.100 extracted from

  • Shi, Y.Q.; Rando, R.R.
    Kinetic mechanism of isoprenylated protein methyltransferase (1992), J. Biol. Chem., 267, 9547-9551.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
methyl ester of N-acetyl-S-farnesyl-L-cysteine
-
Bos taurus
N-acetyl-S-(E,E)-farnesyl-L-cysteine methyl ester mixed-type vs. N-acetyl-S-(E,E)-farnesyl-L-cysteine Bos taurus
S-adenosyl-L-homocysteine competitive vs. S-adenosyl-L-methionine, mixed-type vs. N-acetyl-S-(E,E)-farnesyl-L-cysteine Bos taurus
S-Farnesylthioacetic acid competitive vs. N-acetyl-S-(E,E)-farnesyl-L-cysteine Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.02
-
N-acetyl-S-(E,E)-farnesyl-L-cysteine
-
Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester kinetic mechanism Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
retina
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine
-
Bos taurus S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester
-
?
S-adenosylmethionine + N-acetyl-S-(E,E)-farnesyl-L-cysteine
-
Bos taurus S-adenosylhomocysteine + N-acetyl-S-(E,E)-farnesyl-L-cysteine methyl ester
-
?
S-adenosylmethionine + S-farnesyl-Leu-Ala-Arg-Tyr-Lys-Cys
-
Bos taurus S-adenosylhomocysteine + S-farnesyl-Leu-Ala-Arg-Tyr-Lys-Cys methyl ester
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0012
-
S-Farnesylthioacetic acid
-
Bos taurus
0.0019
-
S-adenosyl-L-homocysteine vs. S-adenosyl-L-methionine Bos taurus
0.0033
-
S-adenosyl-L-homocysteine vs. N-acetyl-S-(E,E)-farnesyl-L-cysteine Bos taurus
0.041
-
N-acetyl-S-(E,E)-farnesyl-L-cysteine methyl ester
-
Bos taurus