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Literature summary for 2.1.1.10 extracted from

  • Perez-Miguelsanz, J.; Vallecillo, N.; Garrido, F.; Reytor, E.; Perez-Sala, D.; Pajares, M.A.
    Betaine homocysteine S-methyltransferase emerges as a new player of the nuclear methionine cycle (2017), Biochim. Biophys. Acta, 1864, 1165-1182 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
K10A about 40% of wild-type activity Rattus norvegicus
K7A slight decrease in activity Rattus norvegicus
K84A about 45% of wild-type activity Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm mainly cytoplasmic localization in liver Rattus norvegicus 5737
-
nucleus in most tissues, low expression of BHMT coincides with a preferential nuclear localization of the protein Rattus norvegicus 5634
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus O09171
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain low expression level Rattus norvegicus
-
cerebellum low expression level Rattus norvegicus
-
kidney high expression level Rattus norvegicus
-
liver highest expression level detected Rattus norvegicus
-
lung low expression level Rattus norvegicus
-
skeletal muscle low expression level Rattus norvegicus
-
testis low expression level Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0044
-
mutant K10A, pH 7.5, 37°C Rattus norvegicus
0.0047
-
mutant K8A, pH 7.5, 37°C Rattus norvegicus
0.0109
-
mutant K7A, pH 7.5, 37°C Rattus norvegicus
0.01215
-
wild-type, pH 7.5, 37°C Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
betaine + L-homocysteine
-
Rattus norvegicus dimethylglycine + L-methionine
-
?

Subunits

Subunits Comment Organism
? x * 45000, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
BHMT
-
Rattus norvegicus

General Information

General Information Comment Organism
physiological function oxidative stress associated with D-galactosamine (Gal) or buthionine sulfoximine (BSO) treatments induces BHMT translocation from cytoplasm to nucleus, which is prevented by administration of N-acetylcysteine and glutathione ethyl ester, respectively. The hepatic nuclear accumulation induced by Gal associates with reduced nuclear BHMT activity and a trend towards increased protein homocysteinylation Rattus norvegicus