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Literature summary for 2.1.1.1 extracted from

  • Ruf, S.; Hallur, M.S.; Anchan, N.K.; Swamy, I.N.; Murugesan, K.R.; Sarkar, S.; Narasimhulu, L.K.; Putta, V.P.R.K.; Shaik, S.; Chandrasekar, D.V.; Mane, V.S.; Kadnur, S.V.; Suresh, J.; Bhamidipati, R.K.; Singh, M.; Burri, R.R.; Kristam, R.; Schreuder, H.; Czech, J.; Rudolph, C.; Marker, A.; Langer, T.; Mullangi,
    Novel nicotinamide analog as inhibitor of nicotinamide N-methyltransferase (2018), Bioorg. Med. Chem. Lett., 28, 922-925 .
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
6-(methylamino)pyridine-3-carboxamide compound inhibits NNMT enzymatic activity and reduces the formation of 1-methyl-nicotinamide by about 80% at 2 h when dosed in mice orally at 50 mg/kg Homo sapiens
6-methoxy-4-methylpyridine-3-carboxamide
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P40261
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000588
-
 pH 7.5, 37°C Homo sapiens 6-(methylamino)pyridine-3-carboxamide
0.000837
-
 pH 7.5, 37°C Homo sapiens 6-methoxy-4-methylpyridine-3-carboxamide