Literature summary for 2.1.1.1 extracted from

Hong, S.; Zhai, B.; Pissios, P.
Nicotinamide N-methyltransferase interacts with enzymes of the methionine cycle and regulates methyl donor metabolism (2018), Biochemistry, 57, 5775-5779 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	O55239	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatocyte	primary hepatocyte	Mus musculus	-

General Information

General Information	Comment	Organism
physiological function	Nnmt overexpression decreases S-adenosyl-L-methionine (SAM) levels and the SAM/S-adenosylhomocysteine (SAH) ratio both in vivo and in vitro. Nnmt knockdown does not change methyl donor balance in mouse primary hepatocytes but increases SAM levels and the SAM/SAH ratio when Gnmt, the dominantly expressed methyltransferase in liver, is simultaneously knocked down. Expression of enzymatically deficient Nnmt increases the SAM/SAH ratio. Proteins Bhmt, Mat1a, and Ahcy, components of the methionine cycle, interact with NNMT in liver. Mutant Nnmt increases the level of remethylation of homocysteine to SAM	Mus musculus

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Release 2023.1 (January 2023)