BRENDA - Enzyme Database show
show all sequences of 2.1.1.1

Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization

Hong, S.; Moreno-Navarrete, J.M.; Wei, X.; Kikukawa, Y.; Tzameli, I.; Prasad, D.; Lee, Y.; Asara, J.M.; Fernandez-Real, J.M.; Maratos-Flier, E.; Pissios, P.; Nat. Med. 21, 887-894 (2015)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
S-adenosyl-L-methionine + nicotinamide
Mus musculus
-
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
?
S-adenosyl-L-methionine + nicotinamide
Mus musculus C57Bl6/J
-
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mus musculus
-
-
-
Mus musculus C57Bl6/J
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
hepatocyte
primary
Mus musculus
-
liver
hepatic expression of Nnmt is highly variable and correlates with multiple metabolic parameters in humans
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
S-adenosyl-L-methionine + nicotinamide
-
734757
Mus musculus
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
?
S-adenosyl-L-methionine + nicotinamide
-
734757
Mus musculus C57Bl6/J
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
?
Cofactor
Cofactor
Commentary
Organism
Structure
S-adenosyl-L-methionine
-
Mus musculus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
S-adenosyl-L-methionine
-
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
S-adenosyl-L-methionine + nicotinamide
Mus musculus
-
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
?
S-adenosyl-L-methionine + nicotinamide
Mus musculus C57Bl6/J
-
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
hepatocyte
primary
Mus musculus
-
liver
hepatic expression of Nnmt is highly variable and correlates with multiple metabolic parameters in humans
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
S-adenosyl-L-methionine + nicotinamide
-
734757
Mus musculus
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
?
S-adenosyl-L-methionine + nicotinamide
-
734757
Mus musculus C57Bl6/J
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
?
Expression
Organism
Commentary
Expression
Mus musculus
hepatic expression of Nnmt is highly variable and correlates with multiple metabolic parameters in mice
additional information
General Information
General Information
Commentary
Organism
malfunction
suppression of hepatic Nnmt expression in vivo alters glucose and cholesterol metabolism. Primary hepatocytes with Nnmt knockdown have signifi­cantly lower hepatocyte glucose output (50%) and significantly lower expression of genes encoding both catalytic glucose-6-phosphatase (20%) and cytosolic phosphoenolpyruvate carboxykinase 1 (40%) compared with control hepatocytes. In contrast, primary hepatocytes in which Nnmt is overexpressed have 1.4fold higher glucose output, threefold higher expression of glucose-6-phosphatase and fourfold higher expression of phosphoenolpyruvate carboxykinase compared with control hepatocytes
Mus musculus
metabolism
enzyme Nnmt regulates glucose and cholesterol metabolism. Sirt1 is required for the metabolic actions of the enzyme, which regulates Sirt1 stability
Mus musculus
physiological function
nicotinamide N-methyltransferase is a metabolic regulator in adipocytes and also regulates hepatic nutrient metabolism through Sirt1 protein stabilization, the metabolic effects of the enzyme in the liver are mediated by its product 1-methylnicotinamide. Nnmt is a positive regulator of gluconeogenesis in primary hepatocytes. Methylation of nicotinamide by Nnmt is a major pathway for the clear­ance of excess vitamin B3 from the body
Mus musculus
General Information (protein specific)
General Information
Commentary
Organism
malfunction
suppression of hepatic Nnmt expression in vivo alters glucose and cholesterol metabolism. Primary hepatocytes with Nnmt knockdown have signifi­cantly lower hepatocyte glucose output (50%) and significantly lower expression of genes encoding both catalytic glucose-6-phosphatase (20%) and cytosolic phosphoenolpyruvate carboxykinase 1 (40%) compared with control hepatocytes. In contrast, primary hepatocytes in which Nnmt is overexpressed have 1.4fold higher glucose output, threefold higher expression of glucose-6-phosphatase and fourfold higher expression of phosphoenolpyruvate carboxykinase compared with control hepatocytes
Mus musculus
metabolism
enzyme Nnmt regulates glucose and cholesterol metabolism. Sirt1 is required for the metabolic actions of the enzyme, which regulates Sirt1 stability
Mus musculus
physiological function
nicotinamide N-methyltransferase is a metabolic regulator in adipocytes and also regulates hepatic nutrient metabolism through Sirt1 protein stabilization, the metabolic effects of the enzyme in the liver are mediated by its product 1-methylnicotinamide. Nnmt is a positive regulator of gluconeogenesis in primary hepatocytes. Methylation of nicotinamide by Nnmt is a major pathway for the clear­ance of excess vitamin B3 from the body
Mus musculus
Expression (protein specific)
Organism
Commentary
Expression
Mus musculus
hepatic expression of Nnmt is highly variable and correlates with multiple metabolic parameters in mice
additional information
Other publictions for EC 2.1.1.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
733279
Liu
Nicotinamide N-methyltransfera ...
Homo sapiens
Biochem. Biophys. Res. Commun.
467
491-496
2015
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1
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1
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2
2
-
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733449
Sartini
Role of nicotinamide N-methylt ...
Homo sapiens
Biol. Chem.
396
225-234
2015
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2
1
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4
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2
2
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733636
Yu
Effects of nicotinamide N-meth ...
Homo sapiens
Cell. Physiol. Biochem.
35
710-721
2015
-
2
1
-
1
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1
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1
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1
1
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1
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2
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1
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-
-
-
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-
2
2
-
-
-
734757
Hong
Nicotinamide N-methyltransfera ...
Mus musculus, Mus musculus C57Bl6/J
Nat. Med.
21
887-894
2015
-
-
-
-
-
-
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2
-
7
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2
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2
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1
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1
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2
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2
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2
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1
3
3
1
-
-
733214
Xie
Nicotinamide N-methyltransfera ...
Homo sapiens
Arch. Biochem. Biophys.
564
52-66
2014
-
-
1
-
1
-
-
-
1
-
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1
-
3
-
-
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-
4
-
-
1
-
1
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1
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-
1
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1
1
-
1
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-
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1
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1
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-
-
-
-
4
-
-
1
-
1
-
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-
1
-
-
-
-
1
1
-
-
-
733614
Bi
N-methylnicotinamide and nicot ...
Homo sapiens
Carcinogenesis
35
2264-2272
2014
-
-
-
-
1
-
-
-
-
-
-
1
-
3
-
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-
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2
-
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1
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1
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1
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1
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1
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2
-
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1
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-
-
-
-
-
1
-
-
1
-
-
733618
Sartini
Nicotinamide N-methyltransfera ...
Homo sapiens
Cell Biochem. Biophys.
67
865-873
2013
-
2
1
-
-
-
-
-
-
-
-
1
-
2
-
-
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-
3
1
-
1
-
1
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1
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1
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2
1
1
-
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1
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3
1
-
1
-
1
-
-
-
1
-
-
-
-
2
2
-
-
-
733625
Thomas
Nicotinamide N-methyltransfera ...
Homo sapiens
Cell Death Dis.
4
e669
2013
-
-
1
-
1
-
-
-
-
-
-
1
-
3
-
-
-
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2
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1
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1
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1
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2
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1
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3
3
-
-
-
734104
Milani
Neuroprotective effects of nic ...
Homo sapiens
J. Biochem. Mol. Toxicol.
27
451-456
2013
-
-
1
-
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1
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1
1
-
-
-
734368
Patel
HPLC-UV method for measuring n ...
Homo sapiens, Mus musculus, Oryctolagus cuniculus
J. Chromatogr. B
921-922
87-95
2013
1
1
-
-
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3
5
3
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6
-
6
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3
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6
-
3
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1
3
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3
3
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1
1
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3
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3
3
5
3
-
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6
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3
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6
-
3
-
-
1
3
-
-
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-
-
735327
Win
Nicotinamide N-methyltransfera ...
Homo sapiens
Tumour Biol.
34
3923-3931
2013
-
-
1
-
1
-
-
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3
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3
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1
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1
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3
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1
3
3
1
-
-
719027
Sartini
Analysis of tissue and salivar ...
Homo sapiens
Biol. Chem.
393
505-511
2012
-
-
-
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1
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2
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1
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1
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1
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1
1
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1
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1
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-
733737
Mori
Toxic effects of nicotinamide ...
Mus musculus
Environ. Health Prev. Med.
17
371-376
2012
-
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2
-
1
1
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1
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2
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2
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1
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1
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1
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2
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1
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1
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1
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2
2
-
-
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718784
Parsons
The expression of nicotinamide ...
Homo sapiens
Biochem. J.
436
145-155
2011
-
-
1
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2
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1
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1
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-
718914
Peng
Structural basis of substrate ...
Homo sapiens
Biochemistry
50
7800-7808
2011
-
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1
1
6
-
-
10
-
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2
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1
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7
-
1
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5
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1
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1
6
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10
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1
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7
-
1
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5
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10
10
719232
Tang
Nicotinamide N-methyltransfera ...
Homo sapiens
Carcinogenesis
32
138-145
2011
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1
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3
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1
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1
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703943
Emanuelli
Nicotinamide N-methyltransfera ...
Homo sapiens
Histol. Histopathol.
25
15-20
2010
-
1
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1
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1
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1
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5
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5
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1
1
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718554
Kim
Expression and functional sign ...
Homo sapiens
Am. J. Respir. Crit. Care Med.
181
797-805
2010
-
-
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2
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6
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6
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1
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1
-
-
701990
Riederer
Adipose tissue as a source of ...
Homo sapiens, Mus musculus
Atherosclerosis
204
412-417
2009
1
-
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1
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2
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5
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8
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2
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1
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1
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2
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1
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2
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1
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2
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8
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2
-
1
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1
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2
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-
2
-
-
704775
Tomida
Serum levels of nicotinamide N ...
Homo sapiens
J. Cancer Res. Clin. Oncol.
135
1223-1229
2009
-
1
1
-
-
-
-
-
-
-
-
1
-
3
-
-
1
-
-
6
-
-
1
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1
1
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1
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1
-
6
-
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1
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-
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-
-
-
-
706094
Mateuszuk
Activation of nicotinamide N-m ...
Mus musculus, Mus musculus C57/BL6J
Pharmacol. Rep.
61
76-85
2009
-
-
-
-
-
-
-
-
1
-
-
2
-
61
-
-
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-
-
10
-
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4
-
1
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1
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1
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1
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-
1
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2
-
-
-
-
-
10
-
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4
-
1
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-
1
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-
1
1
1
1
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1
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Stat3 up-regulates expression ...
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6
1
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Overlapping gene expression pr ...
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Nicotinamide N-methyltransfera ...
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High expression of nicotinamid ...
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A potential role of heat shock ...
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Increased hepatic nicotinamide ...
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Nicotinamide methyltransferase ...
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Mouse liver nicotinamide N-met ...
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441255
Aksoy
Human liver nicotinamide N-met ...
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441253
Rini
Human liver nicotinamide N-met ...
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