Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.1 extracted from

  • Milani, Z.H.; Ramsden, D.B.; Parsons, R.B.
    Neuroprotective effects of nicotinamide N-methyltransferase and its metabolite 1-methylnicotinamide (2013), J. Biochem. Mol. Toxicol., 27, 451-456.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
recombinant ectopic expression of NNMT in enzyme-deficient SH-SY5Y human neuroblastoma cells increasing adenosine triphosphate synthesis and complex I activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + nicotinamide Homo sapiens
-
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain the enzyme is robustly expressed in neurones in all regions of the brain Homo sapiens
-
additional information no enzyme activity in SH-SY5Y human neuroblastoma cells Homo sapiens
-
neuron
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + nicotinamide
-
Homo sapiens S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
?

Synonyms

Synonyms Comment Organism
NNMT
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
Homo sapiens

General Information

General Information Comment Organism
additional information recombinant ectopic expression of NNMT in enzyme-deficient SH-SY5Y human neuroblastoma cells increased adenosine triphosphate synthesis and complex I activity, effects of which are replicated by the addition of 1-methylnicotinamide. The enzyme expression protects against the toxicity of mitochondrial toxins and abolishes the toxic effects of KCN, 2,4-dinitrophenol, and 6-hydroxydopamine, and reduced that of rotenone, while 1-methylnicotinamide significantly reduces the toxicity of rotenone, but has no effect on the toxicity of KCN, 2,4-dinitrophenol, and 6-hydroxydopamine. The enzyme is cytoprotective against toxins that inhibit various aspects of mitochondrial function, which are not mediated solely via increased 1-methylnicotinamide production, but in combination with other unidentified mechanisms Homo sapiens