BRENDA - Enzyme Database show
show all sequences of 2.1.1.1

Nicotinamide N-methyltransferase increases complex I activity in SH-SY5Y cells via sirtuin 3

Liu, K.Y.; Mistry, R.J.; Aguirre, C.A.; Fasouli, E.S.; Thomas, M.G.; Klamt, F.; Ramsden, D.B.; Parsons, R.B.; Biochem. Biophys. Res. Commun. 467, 491-496 (2015)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
recombinant stable expression of NNMT-V5 in SH-SY5Y cells increases complex I activity via sirtuin 3
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
S-adenosyl-L-methionine + nicotinamide
Homo sapiens
-
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
the enzyme is significantly overexpressed in a variety of diseases ranging from cancer to hepatic cirrhosis
Homo sapiens
-
additional information
SH-SY5Y human neuroblastoma cells have no endogenous expression of enzyme NNMT
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
S-adenosyl-L-methionine + nicotinamide
-
733279
Homo sapiens
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
?
Cofactor
Cofactor
Commentary
Organism
Structure
S-adenosyl-L-methionine
-
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
recombinant stable expression of NNMT-V5 in SH-SY5Y cells increases complex I activity via sirtuin 3
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
S-adenosyl-L-methionine
-
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
S-adenosyl-L-methionine + nicotinamide
Homo sapiens
-
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
the enzyme is significantly overexpressed in a variety of diseases ranging from cancer to hepatic cirrhosis
Homo sapiens
-
additional information
SH-SY5Y human neuroblastoma cells have no endogenous expression of enzyme NNMT
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
S-adenosyl-L-methionine + nicotinamide
-
733279
Homo sapiens
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
?
General Information
General Information
Commentary
Organism
additional information
in vitro overexpression of the enzyme has revealed many cytoprotective effects of NNMT, in particular increased complex I activity and ATP synthesis. siRNA-mediated silencing of sirtuin 3 expression decreases complex I activity in NNMT-expressing SH-SY5Y cells to that observed in wild-type SH-SY5Y, and significantly reduces cellular ATP content also
Homo sapiens
physiological function
expression of enzyme NNMT in enzyme-deficient SH-SY5Y human neuroblastoma cells significantly increases the expression of all three sirtuins, class III DNA deacetylase enzymes known to regulate mitochondrial energy production and cell cycle. Sirtuin 3 is a key mediator of NNMT-induced complex I activity and ATP synthesis. Central role for enzyme NNMT in the regulation of energy homeostasis
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
additional information
in vitro overexpression of the enzyme has revealed many cytoprotective effects of NNMT, in particular increased complex I activity and ATP synthesis. siRNA-mediated silencing of sirtuin 3 expression decreases complex I activity in NNMT-expressing SH-SY5Y cells to that observed in wild-type SH-SY5Y, and significantly reduces cellular ATP content also
Homo sapiens
physiological function
expression of enzyme NNMT in enzyme-deficient SH-SY5Y human neuroblastoma cells significantly increases the expression of all three sirtuins, class III DNA deacetylase enzymes known to regulate mitochondrial energy production and cell cycle. Sirtuin 3 is a key mediator of NNMT-induced complex I activity and ATP synthesis. Central role for enzyme NNMT in the regulation of energy homeostasis
Homo sapiens
Other publictions for EC 2.1.1.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
733279
Liu
Nicotinamide N-methyltransfera ...
Homo sapiens
Biochem. Biophys. Res. Commun.
467
491-496
2015
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733449
Sartini
Role of nicotinamide N-methylt ...
Homo sapiens
Biol. Chem.
396
225-234
2015
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2
1
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2
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733636
Yu
Effects of nicotinamide N-meth ...
Homo sapiens
Cell. Physiol. Biochem.
35
710-721
2015
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2
1
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2
2
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734757
Hong
Nicotinamide N-methyltransfera ...
Mus musculus, Mus musculus C57Bl6/J
Nat. Med.
21
887-894
2015
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2
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7
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2
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1
3
3
1
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733214
Xie
Nicotinamide N-methyltransfera ...
Homo sapiens
Arch. Biochem. Biophys.
564
52-66
2014
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1
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1
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1
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733614
Bi
N-methylnicotinamide and nicot ...
Homo sapiens
Carcinogenesis
35
2264-2272
2014
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1
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1
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733618
Sartini
Nicotinamide N-methyltransfera ...
Homo sapiens
Cell Biochem. Biophys.
67
865-873
2013
-
2
1
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1
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1
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2
2
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733625
Thomas
Nicotinamide N-methyltransfera ...
Homo sapiens
Cell Death Dis.
4
e669
2013
-
-
1
-
1
-
-
-
-
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1
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3
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3
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734104
Milani
Neuroprotective effects of nic ...
Homo sapiens
J. Biochem. Mol. Toxicol.
27
451-456
2013
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734368
Patel
HPLC-UV method for measuring n ...
Homo sapiens, Mus musculus, Oryctolagus cuniculus
J. Chromatogr. B
921-922
87-95
2013
1
1
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3
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735327
Win
Nicotinamide N-methyltransfera ...
Homo sapiens
Tumour Biol.
34
3923-3931
2013
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3
3
1
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719027
Sartini
Analysis of tissue and salivar ...
Homo sapiens
Biol. Chem.
393
505-511
2012
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733737
Mori
Toxic effects of nicotinamide ...
Mus musculus
Environ. Health Prev. Med.
17
371-376
2012
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2
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1
1
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1
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2
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2
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718784
Parsons
The expression of nicotinamide ...
Homo sapiens
Biochem. J.
436
145-155
2011
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1
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718914
Peng
Structural basis of substrate ...
Homo sapiens
Biochemistry
50
7800-7808
2011
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1
1
6
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10
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10
10
719232
Tang
Nicotinamide N-methyltransfera ...
Homo sapiens
Carcinogenesis
32
138-145
2011
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703943
Emanuelli
Nicotinamide N-methyltransfera ...
Homo sapiens
Histol. Histopathol.
25
15-20
2010
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1
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718554
Kim
Expression and functional sign ...
Homo sapiens
Am. J. Respir. Crit. Care Med.
181
797-805
2010
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701990
Riederer
Adipose tissue as a source of ...
Homo sapiens, Mus musculus
Atherosclerosis
204
412-417
2009
1
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704775
Tomida
Serum levels of nicotinamide N ...
Homo sapiens
J. Cancer Res. Clin. Oncol.
135
1223-1229
2009
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1
1
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706094
Mateuszuk
Activation of nicotinamide N-m ...
Mus musculus, Mus musculus C57/BL6J
Pharmacol. Rep.
61
76-85
2009
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1
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2
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61
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10
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4
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1
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1
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1
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1
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10
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4
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1
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1
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1
1
1
1
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686485
van Driel
Eight-fold increased risk for ...
Homo sapiens
Eur. Heart J.
29
1424-1431
2008
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1
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687897
Tomida
Stat3 up-regulates expression ...
Homo sapiens
J. Cancer Res. Clin. Oncol.
134
551-559
2008
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1
1
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2
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6
1
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