BRENDA - Reference to 2.1.1.1; Id = 733214

recombinant overexpression of enzyme NNMT in colorectal cancer cells line SW480 which lacks constitutive NNMT expression, quantitative real-time PCR analysis

Homo sapiens

additional information

downregulation of enzyme NNMT expression in HT-29 cells. Balb/c mice are injected with NNMT-transfected SW-480 cells, the enzyme significantly accelerates cell proliferation and enhances tumorigenicity in mice

Homo sapiens

cytoplasm

-

Homo sapiens

5737

-

S-adenosyl-L-methionine + nicotinamide

Homo sapiens

-

S-adenosyl-L-homocysteine + 1-methylnicotinamide

-

?

Homo sapiens

-

colorectal cancer cell

-

Homo sapiens

-

HT-29 cell

exhibit high endogenous expression of enzyme NNMT

Homo sapiens

-

additional information

nicotinamide N-methyltransferase is overexpressed in several malignancies, including colorectal cancer cells. No constitutive expresion of the enzyme in colorectal cancer cells line SW480

Homo sapiens

-

S-adenosyl-L-methionine + nicotinamide

-

733214

Homo sapiens

S-adenosyl-L-homocysteine + 1-methylnicotinamide

-

?

NNMT

-

Homo sapiens

37

-

assay at

Homo sapiens

8.6

-

assay at

Homo sapiens

S-adenosyl-L-methionine

-

Homo sapiens

recombinant overexpression of enzyme NNMT in colorectal cancer cells line SW480 which lacks constitutive NNMT expression, quantitative real-time PCR analysis

Homo sapiens

S-adenosyl-L-methionine

-

Homo sapiens

additional information

downregulation of enzyme NNMT expression in HT-29 cells. Balb/c mice are injected with NNMT-transfected SW-480 cells, the enzyme significantly accelerates cell proliferation and enhances tumorigenicity in mice

Homo sapiens

cytoplasm

-

Homo sapiens

5737

-

S-adenosyl-L-methionine + nicotinamide

Homo sapiens

-

S-adenosyl-L-homocysteine + 1-methylnicotinamide

-

?

colorectal cancer cell

-

Homo sapiens

-

HT-29 cell

exhibit high endogenous expression of enzyme NNMT

Homo sapiens

-

additional information

nicotinamide N-methyltransferase is overexpressed in several malignancies, including colorectal cancer cells. No constitutive expresion of the enzyme in colorectal cancer cells line SW480

Homo sapiens

-

S-adenosyl-L-methionine + nicotinamide

-

733214

Homo sapiens

S-adenosyl-L-homocysteine + 1-methylnicotinamide

-

?

37

-

assay at

Homo sapiens

8.6

-

assay at

Homo sapiens

physiological function

nicotinamide N-methyltransferase is involved in the biotransformation and detoxification of many drugs and xenobiotic compounds, it enhances the capacity of tumorigenesis associated with the promotion of cell cycle progression in human colorectal cancer cells. The enzyme significantly accelerates cell proliferation, enhances colony formation in vitro and tumorigenicity in mice, and inhibits apoptosis, it promotes cell cycle progression, increases ATP and 1-methylnicotinamide level and decreases ROS levels. 1-Methylnicotinamide also accelerates cell growth, inhibits apoptosis, promotes cell cycle progression, attenuates ROS production and increases ATP levels. The enzyme may play a vital role in energy balance and ROS induction, 1-Methylnicotinamide is beneficial in conditions such as inflammation and antioxidation

Homo sapiens

physiological function

nicotinamide N-methyltransferase is involved in the biotransformation and detoxification of many drugs and xenobiotic compounds, it enhances the capacity of tumorigenesis associated with the promotion of cell cycle progression in human colorectal cancer cells. The enzyme significantly accelerates cell proliferation, enhances colony formation in vitro and tumorigenicity in mice, and inhibits apoptosis, it promotes cell cycle progression, increases ATP and 1-methylnicotinamide level and decreases ROS levels. 1-Methylnicotinamide also accelerates cell growth, inhibits apoptosis, promotes cell cycle progression, attenuates ROS production and increases ATP levels. The enzyme may play a vital role in energy balance and ROS induction, 1-Methylnicotinamide is beneficial in conditions such as inflammation and antioxidation

Homo sapiens

733279

Liu

Nicotinamide N-methyltransfera ...

Homo sapiens

Biochem. Biophys. Res. Commun.

467

491-496

2015

-

1

-

1

-

2

-

2

-

1

-

1

-

1

-

1

-

1

-

2

-

1

-

2

-

733449

Sartini

Role of nicotinamide N-methylt ...

Homo sapiens

Biol. Chem.

396

225-234

2015

-

2

1

-

2

-

4

-

1

-

2

1

-

4

-

2

-

733636

Yu

Effects of nicotinamide N-meth ...

Homo sapiens

Cell. Physiol. Biochem.

35

710-721

2015

-

2

1

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

2

1

-

1

-

1

-

2

-

1

-

2

-

734757

Hong

Nicotinamide N-methyltransfera ...

Mus musculus, Mus musculus C57Bl6/J

Nat. Med.

21

887-894

2015

-

2

-

7

-

2

-

2

-

1

-

1

-

1

-

2

-

2

-

2

-

1

3

1

-

733214

Xie

Nicotinamide N-methyltransfera ...

Homo sapiens

Arch. Biochem. Biophys.

564

52-66

2014

-

1

-

1

-

1

-

1

-

3

-

4

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

4

-

1

-

1

-

1

-

1

-

733614

Bi

N-methylnicotinamide and nicot ...

Homo sapiens

Carcinogenesis

35

2264-2272

2014

-

1

-

1

-

3

-

2

-

1

-

1

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

733618

Sartini

Nicotinamide N-methyltransfera ...

Homo sapiens

Cell Biochem. Biophys.

67

865-873

2013

-

2

1

-

1

-

2

-

3

1

-

1

-

1

-

1

-

1

-

2

1

-

1

-

3

1

-

1

-

1

-

1

-

2

-

733625

Thomas

Nicotinamide N-methyltransfera ...

Homo sapiens

Cell Death Dis.

4

e669

2013

-

1

-

1

-

1

-

3

-

2

-

1

-

1

-

1

-

1

-

1

-

1

-

2

-

1

-

3

-

734104

Milani

Neuroprotective effects of nic ...

Homo sapiens

J. Biochem. Mol. Toxicol.

27

451-456

2013

-

1

-

1

-

2

-

3

-

1

-

1

-

1

-

1

-

1

-

3

-

1

-

1

-

734368

Patel

HPLC-UV method for measuring n ...

Homo sapiens, Mus musculus, Oryctolagus cuniculus

J. Chromatogr. B

921-922

87-95

2013

1

-

3

5

3

-

6

-

6

-

3

-

6

-

3

-

1

3

-

3

-

1

-

3

-

3

5

3

-

6

-

3

-

6

-

3

-

1

3

-

735327

Win

Nicotinamide N-methyltransfera ...

Homo sapiens

Tumour Biol.

34

3923-3931

2013

-

1

-

1

-

3

-

3

-

1

-

1

-

1

-

3

-

1

3

1

-

719027

Sartini

Analysis of tissue and salivar ...

Homo sapiens

Biol. Chem.

393

505-511

2012

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

733737

Mori

Toxic effects of nicotinamide ...

Mus musculus

Environ. Health Prev. Med.

17

371-376

2012

-

2

-

1

-

1

-

2

-

2

-

1

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

2

-

1

-

1

-

1

-

2

-

718784

Parsons

The expression of nicotinamide ...

Homo sapiens

Biochem. J.

436

145-155

2011

-

1

-

2

-

1

-

1

-

1

-

1

-

718914

Peng

Structural basis of substrate ...

Homo sapiens

Biochemistry

50

7800-7808

2011

-

1

6

-

10

-

2

-

1

-

7

-

1

-

1

-

5

-

1

-

1

6

-

10

-

1

-

7

-

1

-

5

-

10

719232

Tang

Nicotinamide N-methyltransfera ...

Homo sapiens

Carcinogenesis

32

138-145

2011

-

1

-

3

-

1

-

1

-

1

-

1

-

1

-

703943

Emanuelli

Nicotinamide N-methyltransfera ...

Homo sapiens

Histol. Histopathol.

25

15-20

2010

-

1

-

1

-

1

-

1

-

5

-

1

-

1

-

1

-

1

-

5

-

1

-

718554

Kim

Expression and functional sign ...

Homo sapiens

Am. J. Respir. Crit. Care Med.

181

797-805

2010

-

2

-

6

-

1

-

6

-

1

-

1

-

701990

Riederer

Adipose tissue as a source of ...

Homo sapiens, Mus musculus

Atherosclerosis

204

412-417

2009

1

-

1

-

2

-

5

-

8

-

2

-

2

1

-

1

-

2

-

1

-

2

-

1

-

2

-

8

-

2

-

1

-

1

-

2

-

2

-

704775

Tomida

Serum levels of nicotinamide N ...

Homo sapiens

J. Cancer Res. Clin. Oncol.

135

1223-1229

2009

-

1

-

1

-

3

-

1

-

6

-

1

-

1

-

1

-

1

-

1

-

6

-

1

-

706094

Mateuszuk

Activation of nicotinamide N-m ...

Mus musculus, Mus musculus C57/BL6J

Pharmacol. Rep.

61

76-85

2009

-

1

-

2

-

61

-

10

-

4

-

1

-

1

-

1

-

1

-

1

-

2

-

10

-

4

-

1

-

1

-

1

-

686485

van Driel

Eight-fold increased risk for ...

Homo sapiens

Eur. Heart J.

29

1424-1431

2008

-

1

-

2

-

2

1

-

1

-

1

-

1

-

2

1

-

1

-

687897

Tomida

Stat3 up-regulates expression ...

Homo sapiens

J. Cancer Res. Clin. Oncol.

134

551-559

2008

-

1

-

2

-

1

-

6

1

-

1

-

1

-

1

-

1

-

6

1

-

1

-

702851

Lu

Nicotinamide N-methyl transfer ...

Homo sapiens

Birth Defects Res. Part A Clin. Mol. Teratol.

82

670-675

2008

-

1

-

1

-

4

-

1

-

1

-

1

-

704426

Dostalek

Development of oxidative stres ...

Mus musculus, Mus musculus C57BL/6, Rattus norvegicus

J. Biol. Chem.

283

17147-17157

2008

3

-

2

-

2

-

145

-

2

-

2

-

3

-

2

-

2

-

2

-

706009

Wu

Overlapping gene expression pr ...

Homo sapiens

Oncogene

27

6679-6689

2008

-

1

-

1

-

2

-

5

-

1

-

1

-

1

-

5

-

2

-

689036

Sartini

Nicotinamide N-methyltransfera ...

Homo sapiens

Mol. Med.

13

415-421

2007

-

1

-

1

-

2

1

-

1

-

1

-

1

-

2

1

-

1

-

690123

Zhang

The relation between nicotinam ...

Homo sapiens

Thromb. Res.

121

55-58

2007

-

1

-

2

-

2

1

-

1

-

1

-

1

-

2

1

-

1

-

662513

Xu

Enhanced expression of nicotin ...

Homo sapiens

J. Clin. Endocrinol. Metab.

88

4990-4996

2003

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1

-

2

-

4

-

1

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4

-

662956

Parsons

High expression of nicotinamid ...

Homo sapiens

Neurosci. Lett.

342

13-16

2003

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1

-

3

-

1

-

441260

Kassem

A potential role of heat shock ...

Homo sapiens

Int. J. Cancer

101

454-460

2002

-

1

-

2

-

1

-

1

-

1

-

441262

Parsons

Expression of nicotinamide N-m ...

Homo sapiens

J. Neuropathol. Exp. Neurol.

61

111-124

2002

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1

-

3

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1

-

1

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1

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441259

Aoyama

Nicotinamide-N-methyltransfera ...

Homo sapiens

Neurosci. Lett.

298

78-80

2001

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1

-

2

-

1

-

1

-

1

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441254

Smith

A direct correlation between n ...

Homo sapiens

Biochim. Biophys. Acta

1442

238-244

1998

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2

-

2

-

2

1

-

2

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2

1

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441256

Yan

Mouse nicotinamide N-methyltra ...

Mus musculus

DNA Cell Biol.

17

659-667

1998

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1

-

1

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3

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1

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1

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441261

Okamura

Increased hepatic nicotinamide ...

Mus musculus

Jpn. J. Cancer Res.

89

649-656

1998

-

1

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3

-

3

-

1

-

3

-

441257

Fujimura

Nicotinamide methyltransferase ...

Mus musculus, Rattus norvegicus

Adv. Exp. Med. Biol.

398

507-511

1996

-

2

-

2

-

2

-

2

-

2

-

441258

Scheller

Mouse liver nicotinamide N-met ...

Mus musculus, Mus musculus C57/BL6J

Pharmacogenetics

6

43-53

1996

-

2

1

-

66

-

2

1

-

2

-

1

-

2

1

-

2

1

-

2

-

1

-

441255

Aksoy

Human liver nicotinamide N-met ...

Homo sapiens

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269

14835-14840

1994

-

1

-

1

4

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

4

-

1

-

1

-

1

-

441253

Rini

Human liver nicotinamide N-met ...

Homo sapiens

Clin. Chim. Acta

186

359-374

1990

-

3

2

-

2

-

2

-

1

-

3

-

2

-

2

-

1

-

441252

Alston

Substrate specificity of nicot ...

Sus scrofa

Arch. Biochem. Biophys.

260

601-608

1988

-

2

-

5

-

2

1

-

2

-

1

-

2

1

3

7

1

-

1

-

1

-

2

-

5

-

2

1

-

1

-

2

1

3

7

1

-

1

-

441251

Cantoni

Methylation of nicotinamide wi ...

Rattus norvegicus

J. Biol. Chem.

189

203-217

1951

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

2

-

Nicotinamide N-methyltransferase enhances the capacity of tumorigenesis associated with the promotion of cell cycle progression in human colorectal cancer cells

Data extracted from this reference: