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Literature summary for 2.1.1.1 extracted from

  • Tomida, M.; Mikami, I.; Takeuchi, S.; Nishimura, H.; Akiyama, H.
    Serum levels of nicotinamide N-methyltransferase in patients with lung cancer (2009), J. Cancer Res. Clin. Oncol., 135, 1223-1229.
    View publication on PubMed
Search for more literature for 2.1.1.1

Application

Application Comment Organism
diagnostics NNMT is useful as a biomarker of lung cancer, stages I-III. The sensitivity of the detection in non-small cell lung cancer cells at 90% specficity increases from 25% to 32% when NNMT is used in combination with carcinoembryonic antigen, method development, overview Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene NNMT, expression fo the GST-tagged enzyme in Escherichia coli strain JM109 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens NNMT catalyzes the N-methylation of nicotinamide and other structural analogs, and is involved in the biotransformation of many drugs and xenobiotic compounds ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant GST-tagged enzyme from Escherichia coli strain JM109 by glutathione affinity chromatography and cleavage of the tag by thrombin Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HT-29 cell
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 Homo sapiens
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lung cancer cell serum levels of NNMT are signficantly higher in lung cancer patients, overview Homo sapiens
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MDA-MB-468 cell
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 Homo sapiens
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serum sera from 24 healthy individuals, from 113 non-small cell lung cancer patients undergoing surgery, and from 50 nonneoplastic lung disease patients with chronic obstructive pulmonary disease. Serum levels of NNMT are signficantly higher in lung cancer patients, overview Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information NNMT catalyzes the N-methylation of nicotinamide and other structural analogs, and is involved in the biotransformation of many drugs and xenobiotic compounds Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
NNMT
-
 Homo sapiens