Application | Comment | Organism |
---|---|---|
pharmacology | molecular targets for cancer therapy and diagnosis | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli, NNMT promoter region, promoter-luciferase reporter construct generated, pGL2 vector | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P40261 | - |
- |
Purification (Comment) | Organism |
---|---|
recombinant protein, gel fitration | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | no expression of NNMT in | Homo sapiens | - |
Hep-G2 cell | NNMT expression increased on stimulation of the cells with interleukin 6, NNMT promoter activity dependent on the activation of Stat3 | Homo sapiens | - |
HT-29 cell | colon cancer cells with high and constitutive expression of NNMT | Homo sapiens | - |
MCF-7 cell | no expression of NNMT in | Homo sapiens | - |
MDA-MB-468 cell | breast cancer cells with high and constitutive expression of NNMT | Homo sapiens | - |
SW-480 cell | colon cancer cells, NNMT expression increased on stimulation of the cells with interleukin 6 | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
signal transducers and activators of transcription 3 (Stat3)-regulated genes analyzed, expression of NNMT in cancer cells, promoter activity determined after transfection experiments with NNMT promoter-luciferase reporter construct, real-time PCR, Western-Blot and immunohistochemistry, correlation between the expression of NNMT and activated Stat3 in colon cancer cells, NNMT determined as a Stat3-regulated gene and as a potential tumor marker | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + nicotinamide | NNMT as potential candidate for a tumor marker | Homo sapiens | S-adenosyl-L-homocysteine + 1-methylnicotinamide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NNMT | - |
Homo sapiens |