BRENDA - Enzyme Database show
show all sequences of 2.1.1.1

Human liver nicotinamide N-methyltransferase: ion-pairing radiochemical assay, biochemical properties and individual variation

Rini, J.; Szumlanski, C.; Guerciolini, R.; Weinshilboum, R.M.; Clin. Chim. Acta 186, 359-374 (1990)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
additional information
not inhibitory: Ca2+, SKF 525A, 3,4-dimethoxy-5-hydroxybenzoic acid
Homo sapiens
N1-methylnicotinamide
-
Homo sapiens
S-adenosyl-L-homocysteine
-
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.00176
-
S-adenosyl-L-methionine
-
Homo sapiens
0.347
-
nicotinamide
-
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
S-adenosyl-L-methionine + nicotinamide
-
441253
Homo sapiens
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
?
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
additional information
not inhibitory: Ca2+, SKF 525A, 3,4-dimethoxy-5-hydroxybenzoic acid
Homo sapiens
N1-methylnicotinamide
-
Homo sapiens
S-adenosyl-L-homocysteine
-
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.00176
-
S-adenosyl-L-methionine
-
Homo sapiens
0.347
-
nicotinamide
-
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
S-adenosyl-L-methionine + nicotinamide
-
441253
Homo sapiens
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
?
Other publictions for EC 2.1.1.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
733279
Liu
Nicotinamide N-methyltransfera ...
Homo sapiens
Biochem. Biophys. Res. Commun.
467
491-496
2015
-
-
1
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
733449
Sartini
Role of nicotinamide N-methylt ...
Homo sapiens
Biol. Chem.
396
225-234
2015
-
2
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
2
1
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
733636
Yu
Effects of nicotinamide N-meth ...
Homo sapiens
Cell. Physiol. Biochem.
35
710-721
2015
-
2
1
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
2
1
1
-
1
-
-
-
-
-
-
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-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
734757
Hong
Nicotinamide N-methyltransfera ...
Mus musculus, Mus musculus C57Bl6/J
Nat. Med.
21
887-894
2015
-
-
-
-
-
-
-
-
-
-
-
2
-
7
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
1
3
3
1
-
-
733214
Xie
Nicotinamide N-methyltransfera ...
Homo sapiens
Arch. Biochem. Biophys.
564
52-66
2014
-
-
1
-
1
-
-
-
1
-
-
1
-
3
-
-
-
-
-
4
-
-
1
-
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
4
-
-
1
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
733614
Bi
N-methylnicotinamide and nicot ...
Homo sapiens
Carcinogenesis
35
2264-2272
2014
-
-
-
-
1
-
-
-
-
-
-
1
-
3
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
733618
Sartini
Nicotinamide N-methyltransfera ...
Homo sapiens
Cell Biochem. Biophys.
67
865-873
2013
-
2
1
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
3
1
-
1
-
1
-
-
-
1
-
-
1
-
-
-
-
2
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
1
-
1
-
1
-
-
-
1
-
-
-
-
2
2
-
-
-
733625
Thomas
Nicotinamide N-methyltransfera ...
Homo sapiens
Cell Death Dis.
4
e669
2013
-
-
1
-
1
-
-
-
-
-
-
1
-
3
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
734104
Milani
Neuroprotective effects of nic ...
Homo sapiens
J. Biochem. Mol. Toxicol.
27
451-456
2013
-
-
1
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
734368
Patel
HPLC-UV method for measuring n ...
Homo sapiens, Mus musculus, Oryctolagus cuniculus
J. Chromatogr. B
921-922
87-95
2013
1
1
-
-
-
-
3
5
3
-
-
6
-
6
-
-
-
-
-
3
-
-
6
-
3
-
-
1
3
-
-
3
3
-
-
1
1
-
3
-
-
-
-
3
3
5
3
-
-
6
-
-
-
-
-
3
-
-
6
-
3
-
-
1
3
-
-
-
-
-
-
-
-
-
735327
Win
Nicotinamide N-methyltransfera ...
Homo sapiens
Tumour Biol.
34
3923-3931
2013
-
-
1
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
3
-
-
-
-
-
-
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-
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-
-
-
-
-
-
1
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-
1
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-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
1
3
3
1
-
-
719027
Sartini
Analysis of tissue and salivar ...
Homo sapiens
Biol. Chem.
393
505-511
2012
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
1
-
-
1
1
-
-
-
-
-
-
-
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1
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-
1
-
-
1
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
733737
Mori
Toxic effects of nicotinamide ...
Mus musculus
Environ. Health Prev. Med.
17
371-376
2012
-
-
-
-
-
-
2
-
1
1
-
1
-
2
-
-
-
-
-
2
-
-
1
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
-
1
1
-
1
-
-
-
-
-
2
-
-
1
-
1
-
-
-
1
-
-
-
-
2
2
-
-
-
718784
Parsons
The expression of nicotinamide ...
Homo sapiens
Biochem. J.
436
145-155
2011
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
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-
1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
718914
Peng
Structural basis of substrate ...
Homo sapiens
Biochemistry
50
7800-7808
2011
-
-
1
1
6
-
-
10
-
-
-
-
-
2
-
-
1
-
-
-
7
-
1
-
-
-
-
5
-
-
-
-
-
-
-
-
-
1
-
1
6
-
-
-
-
10
-
-
-
-
-
-
-
1
-
-
7
-
1
-
-
-
-
5
-
-
-
-
-
-
-
-
10
10
719232
Tang
Nicotinamide N-methyltransfera ...
Homo sapiens
Carcinogenesis
32
138-145
2011
-
-
1
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
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1
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1
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-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
703943
Emanuelli
Nicotinamide N-methyltransfera ...
Homo sapiens
Histol. Histopathol.
25
15-20
2010
-
1
-
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
718554
Kim
Expression and functional sign ...
Homo sapiens
Am. J. Respir. Crit. Care Med.
181
797-805
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
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-
-
6
-
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-
6
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
701990
Riederer
Adipose tissue as a source of ...
Homo sapiens, Mus musculus
Atherosclerosis
204
412-417
2009
1
-
-
-
-
-
1
-
-
-
-
2
-
5
-
-
-
-
-
8
-
-
2
-
1
-
-
-
1
-
-
2
-
-
-
1
-
-
2
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
8
-
-
2
-
1
-
-
-
1
-
-
-
2
-
-
2
-
-
704775
Tomida
Serum levels of nicotinamide N ...
Homo sapiens
J. Cancer Res. Clin. Oncol.
135
1223-1229
2009
-
1
1
-
-
-
-
-
-
-
-
1
-
3
-
-
1
-
-
6
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
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-
1
-
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-
1
-
6
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
706094
Mateuszuk
Activation of nicotinamide N-m ...
Mus musculus, Mus musculus C57/BL6J
Pharmacol. Rep.
61
76-85
2009
-
-
-
-
-
-
-
-
1
-
-
2
-
61
-
-
-
-
-
10
-
-
4
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
10
-
-
4
-
1
-
-
-
1
-
-
-
1
1
1
1
-
-
686485
van Driel
Eight-fold increased risk for ...
Homo sapiens
Eur. Heart J.
29
1424-1431
2008
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
1
-
1
-
-
-
-
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-
1
-
-
-
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-
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-
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-
-
-
-
-
-
2
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687897
Tomida
Stat3 up-regulates expression ...
Homo sapiens
J. Cancer Res. Clin. Oncol.
134
551-559
2008
-
1
1
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
6
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
6
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702851
Lu
Nicotinamide N-methyl transfer ...
Homo sapiens
Birth Defects Res. Part A Clin. Mol. Teratol.
82
670-675
2008
-
-
1
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
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-
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1
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1
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-
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-
-
-
-
-
-
-
-
-
-
-
704426
Dostalek
Development of oxidative stres ...
Mus musculus, Mus musculus C57BL/6, Rattus norvegicus
J. Biol. Chem.
283
17147-17157
2008
3
-
-
-
-
-
2
-
2
-
-
-
-
145
-
-
-
-
-
2
-
-
-
-
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