Literature summary for 1.97.1.4 extracted from

Al-Bayati, F.A.; Kahya, H.F.; Damianou, A.; Shafeeq, S.; Kuipers, O.P.; Andrew, P.W.; Yesilkaya, H.
Pneumococcal galactose catabolism is controlled by multiple regulators acting on pyruvate formate lyase (2017), Sci. Rep., 7, 43587 .

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Cloned(Commentary)

Cloned (Comment)	Organism
gene pflA, ligands CcpA, GlnR, and GntR interact with the putative promoters of pflA and pflB, CcpA and GlnR bind to promoters containing cre sites	Streptococcus pneumoniae

Organism

Organism	UniProt	Comment	Textmining
Streptococcus pneumoniae	A0A0H2ZPG2	-	-

Synonyms

Synonyms	Comment	Organism
PFL-AE	-	Streptococcus pneumoniae
PflA	-	Streptococcus pneumoniae
pyruvate formate lyase activating enzyme	-	Streptococcus pneumoniae

Expression

Organism	Comment	Expression
Streptococcus pneumoniae	analysis of the transcriptional regulation of gene pflA, overview	additional information

General Information

General Information	Comment	Organism
malfunction	mutation of either pflB, which codes for PFL, or pflA, which codes for pyruvate formate lyase activating enzyme, results in abrogation of mixed acid fermentation on galactose, and leads to a decrease in pneumococcal virulence	Streptococcus pneumoniae
metabolism	multiple regulators control the transcription of pflA and pflB, some of these regulators are induced by galactose, their control over pflA and pflB is influenced by sodium formate, they exert regulatory influence on each other, and are required for pneumococcal colonization and virulence. Transcriptional profile of mutant DELTApflB compared to the wild-type D39 strain, expression of seven genes annotated as transcriptional regulators is either significantly up or downregulated in the mutant, overview. CcpA, GlnR, and GntR interact with the putative promoters of pflA and pflB, impact of formate on binding affinity of CcpA and GlnR	Streptococcus pneumoniae
physiological function	pyruvate formate lyase (PFL), converting pyruvate to formate and acetyl-CoA, is the key enzyme for mixed acid fermentation. Active pyruvate formate lyase (PFL) synthesis is finely tuned, and feedback inhibition and activation involving the pyruvate formate lyase activating enzyme, are detected, analysis of the transcriptional regulation of gene pflA, overview. The pyruvate formate lyase activating enzyme (PFL-AE) is responsible for posttranslational activation of inactive PFL	Streptococcus pneumoniae

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Release 2023.1 (January 2023)