BRENDA - Enzyme Database show
show all sequences of 1.8.98.2

The dual-targeted plant sulfiredoxin retroreduces the sulfinic form of atypical mitochondrial peroxiredoxin

Iglesias-Baena, I.; Barranco-Medina, S.; Sevilla, F.; Lazaro, J.J.; Plant Physiol. 155, 944-955 (2011)

Data extracted from this reference:

Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
dual localization to plastid and mitochondrion, in line with the prediction of a signal peptide for dual targeting. In mitochondria, enzyme interacts with peroxiredoxin IIF and thioredoxin. Sulfiredoxin catalyzes the retroreduction of the inactive sulfinic form of atypical Prx IIF using thioredoxin as reducing agent
Arabidopsis thaliana
5739
-
mitochondrion
dual localization to plastid and mitochondrion, in line with the prediction of a signal peptide for dual targeting. In mitochondria, enzyme interacts with peroxiredoxin IIF and thioredon. Sulfiredoxin catalyzes the retroreduction of the inactive sulfinic form of atypical Prx IIF using thioredoxin as reducing agent
Pisum sativum
5739
-
plastid
dual localization to plastid and mitochondrion, in line with the prediction of a signal peptide for dual targeting
Arabidopsis thaliana
9536
-
plastid
dual localization to plastid and mitochondrion, in line with the prediction of a signal peptide for dual targeting
Pisum sativum
9536
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Arabidopsis thaliana
Q8GY89
-
-
Pisum sativum
D2KKL9
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
overoxidized human peroxiredoxin V + reduced thioredoxin
Arabidopsis enzyme is able to reduce overoxidized human Prx V
726220
Arabidopsis thaliana
? + oxidized thioredoxin
-
-
-
?
sulfinic form of peroxiredoxin IIF + oxidized thioredoxin
in mitochondria, sulfiredoxin catalyzes the retroreduction of the inactive sulfinic form of atypical peroxiredoxin IIF using thioredoxin as reducing agent
726220
Pisum sativum
? + reduced thioredoxin
-
-
-
?
sulfinic form of peroxiredoxin IIF + reduced thioredoxin
in mitochondria, sulfiredoxin catalyzes the retroreduction of the inactive sulfinic form of atypical peroxiredoxin IIF using thioredoxin as reducing agent
726220
Arabidopsis thaliana
? + oxidized thioredoxin
-
-
-
?
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
dual localization to plastid and mitochondrion, in line with the prediction of a signal peptide for dual targeting. In mitochondria, enzyme interacts with peroxiredoxin IIF and thioredoxin. Sulfiredoxin catalyzes the retroreduction of the inactive sulfinic form of atypical Prx IIF using thioredoxin as reducing agent
Arabidopsis thaliana
5739
-
mitochondrion
dual localization to plastid and mitochondrion, in line with the prediction of a signal peptide for dual targeting. In mitochondria, enzyme interacts with peroxiredoxin IIF and thioredon. Sulfiredoxin catalyzes the retroreduction of the inactive sulfinic form of atypical Prx IIF using thioredoxin as reducing agent
Pisum sativum
5739
-
plastid
dual localization to plastid and mitochondrion, in line with the prediction of a signal peptide for dual targeting
Arabidopsis thaliana
9536
-
plastid
dual localization to plastid and mitochondrion, in line with the prediction of a signal peptide for dual targeting
Pisum sativum
9536
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
overoxidized human peroxiredoxin V + reduced thioredoxin
Arabidopsis enzyme is able to reduce overoxidized human Prx V
726220
Arabidopsis thaliana
? + oxidized thioredoxin
-
-
-
?
sulfinic form of peroxiredoxin IIF + oxidized thioredoxin
in mitochondria, sulfiredoxin catalyzes the retroreduction of the inactive sulfinic form of atypical peroxiredoxin IIF using thioredoxin as reducing agent
726220
Pisum sativum
? + reduced thioredoxin
-
-
-
?
sulfinic form of peroxiredoxin IIF + reduced thioredoxin
in mitochondria, sulfiredoxin catalyzes the retroreduction of the inactive sulfinic form of atypical peroxiredoxin IIF using thioredoxin as reducing agent
726220
Arabidopsis thaliana
? + oxidized thioredoxin
-
-
-
?
Other publictions for EC 1.8.98.2
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
742457
Shi
Sulfiredoxin involved in the ...
Rattus norvegicus
Exp. Cell Res.
352
273-280
2017
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
742601
Calderon
Glutathionylation of pea chlo ...
Pisum sativum
Front. Plant Sci.
8
118
2017
-
-
1
-
-
-
-
-
2
-
-
-
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
742566
Rhee
Mitochondrial H2O2 signaling ...
Mus musculus
Free Radic. Biol. Med.
99
120-127
2016
-
-
-
-
-
-
-
-
1
-
-
1
-
2
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
742996
Sevilla
The thioredoxin/peroxiredoxin ...
Arabidopsis thaliana
J. Exp. Bot.
66
2945-2955
2015
-
-
-
-
-
-
-
-
2
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
724192
Moon
Reversal of 2-Cys peroxiredoxi ...
Saccharomyces cerevisiae
Biochem. Biophys. Res. Commun.
432
291-295
2013
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
743135
Li
Sulfiredoxin-1 protects PC12 ...
Rattus norvegicus
J. Neurosci. Res.
91
861-870
2013
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
743228
Kil
Study of the signaling functi ...
Mus musculus
Methods Enzymol.
527
169-181
2013
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
725015
Chi
Dual functions of Arabidopsis ...
Arabidopsis thaliana
FEBS Lett.
586
3493-3499
2012
-
-
1
-
1
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
725510
Baek
Sulfiredoxin protein is critic ...
Mus musculus
J. Biol. Chem.
287
81-89
2012
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
725010
Roussel
The rate-limiting step of sulf ...
Saccharomyces cerevisiae
FEBS Lett.
585
574-578
2011
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
726220
Iglesias-Baena
The dual-targeted plant sulfir ...
Arabidopsis thaliana, Pisum sativum
Plant Physiol.
155
944-955
2011
-
-
-
-
-
-
-
-
5
-
-
-
-
6
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
712607
Iglesias-Baena
Characterization of plant sulf ...
Arabidopsis thaliana, Arabidopsis thaliana Columbia
J. Exp. Bot.
61
1509-1521
2010
-
-
1
-
6
-
-
3
1
1
2
-
-
11
-
-
1
-
-
1
-
-
8
1
1
-
-
2
1
-
-
1
-
1
-
-
-
1
1
-
6
-
-
-
-
3
1
1
2
-
-
-
-
1
-
1
-
-
8
1
1
-
-
2
1
-
-
1
-
1
1
-
-
-
695553
Kim
A colorimetric assay for sulfi ...
Homo sapiens
Anal. Biochem.
393
36-40
2009
-
1
1
-
1
-
1
-
-
1
-
1
-
2
-
-
1
-
-
-
-
-
1
-
2
-
-
-
1
-
-
3
-
-
-
-
1
1
3
-
1
-
-
1
-
-
-
1
-
1
-
-
-
1
-
-
-
-
1
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
698052
Singh
Nrf2-dependent sulfiredoxin-1 ...
Homo sapiens, Mus musculus
Free Radic. Biol. Med.
46
376-386
2009
-
2
1
-
-
-
2
-
-
-
-
2
-
4
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
4
-
-
4
-
-
698928
Park
Deglutathionylation of 2-Cys p ...
Homo sapiens
J. Biol. Chem.
284
23364-23374
2009
-
-
1
-
3
-
1
-
-
1
-
1
-
1
-
-
1
-
-
2
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
2
-
3
-
-
1
-
-
-
1
-
1
-
-
-
1
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698953
Roussel
The catalytic mechanism of Sul ...
Saccharomyces cerevisiae
J. Biol. Chem.
284
33048-33055
2009
-
-
1
-
3
-
-
-
-
-
1
1
-
3
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
3
-
3
-
-
-
-
-
-
-
1
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698993
Noh
Sulfiredoxin Translocation int ...
Homo sapiens
J. Biol. Chem.
284
8470-8477
2009
-
-
1
-
1
-
-
-
2
-
-
1
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687747
Roussel
Evidence for the formation of ...
Saccharomyces cerevisiae
J. Biol. Chem.
283
22371-22382
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687749
Joensson
Identification of intact prote ...
Homo sapiens
J. Biol. Chem.
283
22890-22894
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688522
Soriano
Induction of sulfiredoxin expr ...
Rattus norvegicus
J. Neurochem.
107
533-543
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689157
Joensson
Structure of the sulphiredoxin ...
Homo sapiens
Nature
451
98-101
2008
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700520
Lei
Protein cysteine sulfinic acid ...
Homo sapiens
Oncogene
27
4877-4887
2008
-
1
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
3
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
3
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
670564
Rey
The Arabidopsis thaliana sulfi ...
Arabidopsis thaliana
Plant J.
49
505-514
2007
-
-
1
-
-
-
-
-
3
-
1
1
-
6
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
3
-
1
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
667711
Lee
Mutagenesis and modeling of th ...
Homo sapiens
Biochemistry
45
15301-15309
2006
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668161
Findlay
A novel role for human sulfire ...
Homo sapiens
Cancer Res.
66
6800-6806
2006
-
-
1
-
1
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668202
Liu
Molecular and functional chara ...
Arabidopsis thaliana, Oryza sativa
Cell Res.
16
287-296
2006
-
-
2
-
-
-
-
-
2
-
-
-
-
8
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
669451
Jeong
Molecular mechanism of the red ...
Homo sapiens
J. Biol. Chem.
281
14400-14407
2006
1
-
-
-
8
-
-
-
-
1
1
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
8
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
670504
Jang
-
Structural and functional regu ...
Homo sapiens, Saccharomyces cerevisiae
Physiol. Plant.
126
549-559
2006
-
-
-
-
-
-
-
-
-
2
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
658132
Jönsson
Structural basis for the retro ...
Homo sapiens
Biochemistry
44
8634-8642
2005
-
-
-
1
-
-
-
-
-
-
-
1
-
2
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
658255
Findlay
Sulfiredoxin: a potential ther ...
Homo sapiens
Biomed. Pharmacother.
59
374-379
2005
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659491
Woo
Reduction of cysteine sulfinic ...
Rattus norvegicus
J. Biol. Chem.
280
3125-3128
2005
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659421
Chang
Characterization of mammalian ...
Homo sapiens, Mus musculus, Rattus norvegicus
J. Biol. Chem.
279
50994-51001
2004
-
-
3
-
-
-
-
3
1
-
-
1
-
6
-
-
1
-
-
6
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
3
1
-
-
1
-
-
-
1
-
6
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659998
Biteau
ATP-dependent reduction of cys ...
Saccharomyces cerevisiae
Nature
425
980-984
2003
-
-
-
-
-
-
-
-
-
1
-
1
-
5
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-