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Literature summary for 1.8.98.2 extracted from

  • Chang, T.S.; Jeong, W.; Woo, H.A.; Lee, S.M.; Park, S.; Rhee, S.G.
    Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine (2004), J. Biol. Chem., 279, 50994-51001.
    View publication on PubMed
Search for more literature for 1.8.98.2

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Mus musculus
expression in Escherichia coli Homo sapiens
expression in Escherichia coli Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0012
-
 thioredoxin 1
-
 Homo sapiens
0.03
-
 ATP
-
 Homo sapiens
1.8
-
 GSH
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH Homo sapiens Srx is largely responsible for reduction of the Cys-SO2H of peroxiredoxin in A549 human cells peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
lung
-
 Homo sapiens
-
spleen
-
 Homo sapiens
-
thymus
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no activity with CTP, UTP, dCTP, or dTTP Homo sapiens ?
-
 ?
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH
-
 Mus musculus peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
 ?
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH
-
 Rattus norvegicus peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
 ?
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH Srx is largely responsible for reduction of the Cys-SO2H of peroxiredoxin in A549 human cells Homo sapiens peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
 ?
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH both glutathione and thioredoxin are potential physiological electron donors Homo sapiens peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
 ?
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + GSH
-
 Homo sapiens peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + GSSG
-
 ?
peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + thioredoxin 1
-
 Homo sapiens peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + thioredoxin 1 disulfide
-
 r
peroxiredoxin-(S-hydroxy-S-oxocysteine) + dATP + 2 R-SH both glutathione and thioredoxin are potential physiological electron donors Homo sapiens peroxiredoxin-(S-hydroxycysteine) + dADP + phosphate + R-S-S-R
-
 ?
peroxiredoxin-(S-hydroxy-S-oxocysteine) + dGTP + 2 R-SH both glutathione and thioredoxin are potential physiological electron donors Homo sapiens peroxiredoxin-(S-hydroxycysteine) + GDP + phosphate + R-S-S-R
-
 ?
peroxiredoxin-(S-hydroxy-S-oxocysteine) + GTP + 2 R-SH both glutathione and thioredoxin are potential physiological electron donors Homo sapiens peroxiredoxin-(S-hydroxycysteine) + GDP + phosphate + R-S-S-R
-
 ?

Synonyms

Synonyms Comment Organism
Srx
-
 Mus musculus
Srx
-
 Homo sapiens
Srx
-
 Rattus norvegicus