Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Mersalyl acid | - |
Methanosarcina thermophila |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.092 | - |
dihydromethanophenazine | 25°C | Methanosarcina thermophila | |
0.144 | - |
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine | 25°C | Methanosarcina thermophila |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Iron | contains two [Fe4S4] clusters. Only the low spin heme and the high potential FeS cluster are involved in reduction of N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine. A 4 Fe cluster is the initial electron acceptor | Methanosarcina thermophila |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
coenzyme B + coenzyme M + methanophenazine | Methanosarcina thermophila | - |
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydromethanophenazine | - |
? | |
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydromethanophenazine | Methanosarcina thermophila | - |
coenzyme B + coenzyme M + methanophenazine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Methanosarcina thermophila | - |
- |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
52 | - |
- |
Methanosarcina thermophila |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
coenzyme B + coenzyme M + methanophenazine | - |
Methanosarcina thermophila | N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydromethanophenazine | - |
? | |
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydromethanophenazine | - |
Methanosarcina thermophila | coenzyme B + coenzyme M + methanophenazine | - |
? | |
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + dihydromethanophenazine | ping-pong mechanism | Methanosarcina thermophila | coenzyme B + coenzyme M + methanophenazine | - |
? | |
N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine + reduced methyl viologen | ping-pong mechanism | Methanosarcina thermophila | coenzyme B + coenzyme M + methyl viologen | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HDR | - |
Methanosarcina thermophila |
heterodisulfide reductase | - |
Methanosarcina thermophila |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
74 | - |
dihydromethanophenazine | 25°C | Methanosarcina thermophila |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | contains two b-hemes. Only the low spin heme and the high potential FeS cluster are involved in reduction of N-(7-[(2-sulfoethyl)dithio]heptanoyl)-3-O-phospho-L-threonine | Methanosarcina thermophila |