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Literature summary for 1.8.5.9 extracted from

  • Kadokura, H.; Beckwith, J.
    Four cysteines of the membrane protein DsbB act in concert to oxidize its substrate DsbA (2002), EMBO J., 21, 2354-2363 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.8.5.9

Protein Variants

Protein Variants Comment Organism
R48H the mutant shows reduced activity compared to the wild type enzyme Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasmic membrane
-
 Escherichia coli
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a [DsbA protein] with reduced L-cysteine residues + a quinone Escherichia coli overall reaction a [DsbA protein] carrying a disulfide bond + a quinol
-
 ?
a [DsbA protein] with reduced L-cysteine residues + a [DsbB protein] carrying a disulfide bond Escherichia coli
-
 a [DsbA protein] carrying a disulfide bond + a [DsbB protein] with reduced L-cysteine residues
-
 ?
a [DsbB protein] with reduced L-cysteine residues + a quinone Escherichia coli
-
 a [DsbB protein] carrying a disulfide bond + a quinol
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a [DsbA protein] with reduced L-cysteine residues + a quinone overall reaction Escherichia coli a [DsbA protein] carrying a disulfide bond + a quinol
-
 ?
a [DsbA protein] with reduced L-cysteine residues + a [DsbB protein] carrying a disulfide bond
-
 Escherichia coli a [DsbA protein] carrying a disulfide bond + a [DsbB protein] with reduced L-cysteine residues
-
 ?
a [DsbB protein] with reduced L-cysteine residues + a quinone
-
 Escherichia coli a [DsbB protein] carrying a disulfide bond + a quinol
-
 ?
additional information the enzyme uses its two pairs of cysteines in a coordinated reaction to accept electrons from the active cysteines in DsbA protein Escherichia coli ?
-
-

Synonyms

Synonyms Comment Organism
DsbB
-
 Escherichia coli