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Literature summary for 1.8.5.9 extracted from
- Structure and mechanisms of the DsbB-DsbA disulfide bond generation machine (2008), Biochim. Biophys. Acta Mol. Cell Res., 1783, 520-529 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasmic membrane | - |
Escherichia coli | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| a [DsbA protein] with reduced L-cysteine residues + a [DsbB protein] carrying a disulfide bond | Escherichia coli | - |
a [DsbA protein] carrying a disulfide bond + a [DsbB protein] with reduced L-cysteine residues | - |
? |  |
| a [DsbA protein] with reduced L-cysteine residues + ubiquinone | Escherichia coli | overall reaction | a [DsbA protein] carrying a disulfide bond + ubiquinol | - |
? | |
| a [DsbB protein] with reduced L-cysteine residues + ubiquinone | Escherichia coli | - |
a [DsbB protein] carrying a disulfide bond + ubiquinol | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| a [DsbA protein] with reduced L-cysteine residues + a [DsbB protein] carrying a disulfide bond | - |
Escherichia coli | a [DsbA protein] carrying a disulfide bond + a [DsbB protein] with reduced L-cysteine residues | - |
? | |
| a [DsbA protein] with reduced L-cysteine residues + ubiquinone | overall reaction | Escherichia coli | a [DsbA protein] carrying a disulfide bond + ubiquinol | - |
? | |
| a [DsbB protein] with reduced L-cysteine residues + ubiquinone | - |
Escherichia coli | a [DsbB protein] carrying a disulfide bond + ubiquinol | - |
? | |
| additional information | the enzyme gains the ability to oxidize its specific substrate, DsbA protein, having very high redox potential, by undergoing a DsbA-induced rearrangement of cysteine residues. One of the enzyme cysteines that are now reduced then interacts with ubiquinone to form a charge transfer complex, leading to the regeneration of a disulfide at the enzyme active site | Escherichia coli | ? | - |
- |
|
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DsbB | - |
Escherichia coli |
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Release 2023.1 (January 2023)
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