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Literature summary for 1.8.5.4 extracted from

  • Zhang, X.; Xin, Y.; Chen, Z.; Xia, Y.; Xun, L.; Liu, H.
    Sulfide-quinone oxidoreductase is required for cysteine synthesis and indispensable to mitochondrial health (2021), Redox Biol., 47, 102169 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene ht2, quantitative RT-PCR enzyme expression analysis Schizosaccharomyces pombe

Protein Variants

Protein Variants Comment Organism
additional information construction and analysis of an enzyme knockout strain DELTAsqr, phenotypes, overview Schizosaccharomyces pombe

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Schizosaccharomyces pombe 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
n H2S + n quinone Schizosaccharomyces pombe
-
polysulfide + n quinol
-
?
n H2S + n quinone Schizosaccharomyces pombe ATCC 24843
-
polysulfide + n quinol
-
?
n H2S + n quinone Schizosaccharomyces pombe 972
-
polysulfide + n quinol
-
?

Organism

Organism UniProt Comment Textmining
Schizosaccharomyces pombe O94284
-
-
Schizosaccharomyces pombe 972 O94284
-
-
Schizosaccharomyces pombe ATCC 24843 O94284
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
n H2S + n quinone
-
Schizosaccharomyces pombe polysulfide + n quinol
-
?
n H2S + n quinone
-
Schizosaccharomyces pombe ATCC 24843 polysulfide + n quinol
-
?
n H2S + n quinone
-
Schizosaccharomyces pombe 972 polysulfide + n quinol
-
?

Synonyms

Synonyms Comment Organism
HMT2
-
Schizosaccharomyces pombe
SQR
-
Schizosaccharomyces pombe
sulfide-quinone oxidoreductase
-
Schizosaccharomyces pombe

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Schizosaccharomyces pombe

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Schizosaccharomyces pombe

General Information

General Information Comment Organism
malfunction enzyme Sqr knockout leads to morphological changes and functional deficiencies of mitochondria and apoptosis in Schizosaccharomyces pombe. The Sqr knockout strain displays the same phenotypes as the cysteine-synthesis-deficient strain. Cysteine addition complements the effects caused by Sqr knockout. Sqr knockout also results in physiological changes. The DELTAsqr strain shows reduced cell viability compared to the wild-type strain when cultivated in YES medium. There are more cells of early apoptosis in DELTAsqr culture than that in wild-type culture. Sqr knockout impaires mitochondrial health. Phenotypes and transcription and metabolism changes caused by sqr knockout, overview Schizosaccharomyces pombe
metabolism in Schizosaccharomyces pombe, Sqr is the main reactive sulfur species (RSS) producer in mitochondria, and RSS instead of H2S is used by cysteine synthase to synthesize cysteine. In terms of RSS metabolism, Schizosaccharomyces pombe does not contain genes encoding cystathionine beta-synthase (Cbs), cystathionine gamma-lyase (Cse), cysteinyl-tRNA synthetase 2 (Crs2), or persulfide dioxygenase (Pdo) Schizosaccharomyces pombe
additional information reactive sulfur species (RSS) include inorganic polysulfide (HSnH, n>2), organic polysulfide (RSnH, n>2), and polysulfane (RSnR, n>2) Schizosaccharomyces pombe
physiological function sulfide:quinone oxidoreductase (Sqr), which oxidizes hydrogen sulfide to reactive sulfur species (RSS), is indispensable to mitochondria health in the eukaryotic model microorganism Schizosaccharomyces pombe. RSS play critical functions in the cell, such as signaling, redox homeostasis maintenance, and metabolic regulation Schizosaccharomyces pombe