Literature summary for 1.8.5.4 extracted from

Libiad, M.; Yadav, P.; Vitvitsky, V.; Martinov, M.; Banerjee, R.
Organization of the human mitochondrial hydrogen sulfide oxidation pathway (2014), J. Biol. Chem., 289, 30901-30910.

Search for more literature for 1.8.5.4

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.32	-	Sulfide	pH 7.4, 25°C	Homo sapiens
2	3	cysteine	pH 7.4, 25°C	Homo sapiens
22	-	reduced glutathione	pH 7.4, 25°C	Homo sapiens
22	-	homocysteine	pH 7.4, 25°C	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
sulfide + cysteine + coenzyme Q1	-	Homo sapiens	cysteine persulfide + reduced coenzyme Q1	-	?
sulfide + homocysteine + coenzyme Q1	-	Homo sapiens	homocysteine persulfide + reduced coenzyme Q1	-	?
sulfide + reduced glutathione + coenzyme Q1	-	Homo sapiens	glutathione persulfide + reduced coenzyme Q1	-	?

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
74	-	Sulfide	pH 7.4, 25°C	Homo sapiens
92	-	homocysteine	pH 7.4, 25°C	Homo sapiens
94	-	cysteine	pH 7.4, 25°C	Homo sapiens
113	-	reduced glutathione	pH 7.4, 25°C	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	human sulfide quinone oxidoreductase uses glutathione as an acceptor forming glutathione persulfide (GSSH), which is preferentially converted to thiosulfate by human rhodanese	Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs^-1]	kcat/KM Value Maximum [1/mMs^-1]	Substrate	Comment	Organism	Structure
2.3	-	Sulfide	pH 7.4, 25°C	Homo sapiens
4.1	-	cysteine	pH 7.4, 25°C	Homo sapiens
4.2	-	homocysteine	pH 7.4, 25°C	Homo sapiens
5.1	-	reduced glutathione	pH 7.4, 25°C	Homo sapiens

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Release 2023.1 (January 2023)