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Literature summary for 1.8.5.3 extracted from

  • Wells, M.; Kanmanii, N.J.; Al Zadjali, A.M.; Janecka, J.E.; Basu, P.; Oremland, R.S.; Stolz, J.F.
    Methane, arsenic, selenium and the origins of the DMSO reductase family (2020), Sci. Rep., 10, 10946 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.8.5.3

Cloned(Commentary)

Cloned (Comment) Organism
gene dmsA, DNA and amino acid sequence comparisons and phylogenetic analysis, detailed overview Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Molybdenum required Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dimethylsulfoxide + menaquinol Escherichia coli
-
 dimethylsulfide + menaquinone + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli P18775
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dimethylsulfoxide + menaquinol
-
 Escherichia coli dimethylsulfide + menaquinone + H2O
-
 ?

Synonyms

Synonyms Comment Organism
dimethyl sulfoxide reductase
-
 Escherichia coli
DmsA
-
 Escherichia coli
DMSO reductase
-
 Escherichia coli
DMSOR
-
 Escherichia coli
respiratory dimethyl sulfoxide reductase
-
 Escherichia coli

Cofactor

Cofactor Comment Organism Structure
molybdenum cofactor
-
 Escherichia coli

General Information

General Information Comment Organism
evolution ubiquitous in Archaea and Bacteria, mononuclear molybdoenzymes of the dimethyl sulfoxide reductase (DMSOR) family are believed to have been core components of the first anaerobic respiratory chains, and thus present at life's origins. The family, which has been defined by the presence of a mononuclear molybdopterin or tungstopterin bis(pyranopterin guanine dinucleotide) (Mo/W-bisPGD) cofactor, is named after DMSO reductases, the first members of the family to be well-characterized. Phylogenetic analysis of DMSOR family clades and members, detailed overview. The enzyme belongs to a clade of DMSOR members that include the respiratory dimethyl sulfoxide reductase (DmsA), respiratory nitrate reductase (NarG), PsrA/PhsA/SrrA, ArxA/ArrA, and TtrA/SrdA/archaeal arsenate reductase lineages that interact with the membrane quinone pool during anaerobic respiration using the canonical subunits. The association of DMSOR members with characteristic electron transfer and membrane anchor subunits arose once early in the evolution of DSMORs and co-evolved with these representatives through multiple diversification events Escherichia coli