Literature summary for 1.8.4.2 extracted from

Davey, L.; Halperin, S.; Lee, S.
Mutation of the thiol-disulfide oxidoreductase SdbA activates the CiaRH two-component system, leading to bacteriocin expression shutdown in Streptococcus gordonii (2016), J. Bacteriol., 198, 321-331 .

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Organism

Organism	UniProt	Comment	Textmining
Streptococcus gordonii	-	-	-
Streptococcus gordonii SecCR1	-	-	-

Synonyms

Synonyms	Comment	Organism
SdbA	-	Streptococcus gordonii

General Information

General Information	Comment	Organism
physiological function	inactivation of SdbA results in enhanced biofilm formation. Biofilm formation is mediated by the interaction between the CiaRH and ComDE two-component signalling systems. CiaRH is upregulated in the SdbA mutant and is essential for the enhanced biofilm phenotype. The enhanced biofilm phenotype also corresponds to increased oral colonization in mice	Streptococcus gordonii
physiological function	SdbA mutants lack bacteriocin activity due to strong repression of bacteriocin gene. The Com pathway is functional but not activated in the SdbA mutant. Repression of bacteriocin production is mediated by the CiaRH two-component system, which is strongly upregulated in the sdbA mutant. The CiaRH-induced protease DegP is also upregulated in the SdbA mutant	Streptococcus gordonii

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Release 2023.1 (January 2023)