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Literature summary for 1.8.4.2 extracted from

  • Kleemann, R.; Rorsman, H.; Rosengren, E.; Mischke, R.; Mai, N.T.; Bernhagen, J.
    Dissection of the enzymatic and immunologic functions of macrophage migration inhibitory factor. Full immunologic activity of N-terminally truncated mutants (2000), Eur. J. Biochem., 267, 7183-7192.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
cysteine disulfide cysteine residues in the redox active catalytic center are essential for conformation stability Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression from plasmid in bacterial expression system, amino acid analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
C57S site-directed mutagenesis, reduced activity Homo sapiens
C57S/C60S site-directed mutagenesis, no activity Homo sapiens
C60S site-directed mutagenesis, no activity Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
12000
-
? * 12000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
macrophage migration inhibitory factor is a cytokine and pituitary hormone
-

Purification (Commentary)

Purification (Comment) Organism
recombinant wild-type and mutant enzymes Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
2 glutathione + protein-disulfide = glutathione-disulfide + protein-dithiol C-X-X-C motif in active site for disulfide bonding, either oxidizing, reducing and isomerising activity Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GSH + insulin
-
Homo sapiens GSSG + reduced insulin chain A and B
-
?

Subunits

Subunits Comment Organism
? ? * 12000, SDS-PAGE Homo sapiens