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Literature summary for 1.8.4.2 extracted from

  • Chandler, M.L.; Varandani, P.T.
    Kinetic analysis of the mechanism of insulin degradation by glutathione-insulin transhydrogenase (thiol: protein-disulfide oxidoreductase) (1975), Biochemistry, 14, 2107-2115.
    View publication on PubMed
Search for more literature for 1.8.4.2

Inhibitors

Inhibitors Comment Organism Structure
GSSG product inhibition Bos taurus
additional information overview product inhibition Bos taurus
S-Sulfonated A-chain or B-chain of insulin product inhibition Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information Km values for insulin at various fixed thiol concentrations and for various thiol compounds at fixed insulin concentrations Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
2 glutathione + protein-disulfide = glutathione-disulfide + protein-dithiol random mechanism Bos taurus
a

Source Tissue

Source Tissue Comment Organism Textmining
pancreas
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,3-dimercaptopropanol + protein disulfide
-
 Bos taurus 2,3-dimercaptopropanol disulfide + protein-dithiol
-
 ?
2-mercaptoethanol + protein disulfide
-
 Bos taurus 2-mercaptoethanol disulfide + protein-dithiol
-
 ?
dihydrolipoate + protein disulfide
-
 Bos taurus ?
-
 ?
dithiothreitol + protein disulfide
-
 Bos taurus ?
-
 ?
GSH + insulin
-
 Bos taurus GSSG + reduced insulin chain A and B
-
 ?
GSH + protein disulfide
-
 Bos taurus GSSG + protein-dithiol
-
 r
GSSG + reduced ribonuclease
-
 Bos taurus GSH + oxidized ribonuclease
-
 ?