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Literature summary for 1.8.4.12 extracted from

  • Guerrero, S.A.; Arias, D.G.; Cabeza, M.S.; Law, M.C.Y.; DAmico, M.; Kumar, A.; Wilkinson, S.R.
    Functional characterisation of the methionine sulfoxide reductase repertoire in Trypanosoma brucei (2017), Free Radic. Biol. Med., 112, 524-533 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli BL21 (DE3) Trypanosoma brucei

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.429
-
N-acetyl-L-methionine-(R)-S-oxide pH 7.5, 30°C Trypanosoma brucei
1.8
-
tryparedoxin pH 7.5, 30°C Trypanosoma brucei

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Trypanosoma brucei 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
20000
-
-
Trypanosoma brucei

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Trypanosoma brucei

Source Tissue

Source Tissue Comment Organism Textmining
trypomastigote
-
Trypanosoma brucei
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-L-methionine-(R)-S-oxide + tryparedoxin
-
Trypanosoma brucei N-acetyl-L-methionine + tryparedoxin disulfide + H2O
-
?

Synonyms

Synonyms Comment Organism
TbmsrB
-
Trypanosoma brucei

General Information

General Information Comment Organism
physiological function to combat the deleterious effects that oxidation of the sulfur atom in methionine to sulfoxide may bring, aerobic cells express repair pathways involving methionine sulfoxide reductases (MSRs) to reverse the deleterious reaction Trypanosoma brucei