Literature summary for 1.8.4.12 extracted from

Wen, Y.; Peng, L.; Zhou, Y.; Peng, T.; Chen, Y.; Cheng, X.; Chen, Y.; Yang, J.
Discovery and application of methionine sulfoxide reductase B for preparation of (S)-sulfoxides through kinetic resolution (2020), Catal. Commun., 136, 105908 .

No PubMed abstract available

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Application

Application	Comment	Organism
synthesis	application of methionine sulfoxide reductase B for preparation of (S)-sulfoxides through kinetic resolution of racemic sulfoxides. The kinetic resolution of rac-sulfoxides is successfully accomplished at substrate concentrations up to 50 mM (7.8 g/l) when catalyzed by akMsrB whole-cell catalyst. The study supports that asymmetric reductive resolution of rac-sulfoxides catalysed by MsrB can become an effective strategy for green synthesis of optically pure sulfoxides	Acidovorax sp. KKS102

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Acidovorax sp. KKS102

Organism

Organism	UniProt	Comment	Textmining
Acidovorax sp. KKS102	K0HZZ3	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
racemic (ethanesulfinyl)benzene + dithiothreitol	specifically reduces the (R)-enantiomer of methionine sulfoxide to methionine, 93.1% ee	Acidovorax sp. KKS102	(ethylsulfanyl)benzene + [(S)-ethanesulfinyl]benzene + dithiothreitol disulfide + H2O	-	?
racemic (methanesulfinyl)benzene + dithiothreitol	specifically reduces the (R)-enantiomer of methionine sulfoxide to methionine, 96% ee	Acidovorax sp. KKS102	(methylsulfanyl)benzene + [(S)-methanesulfinyl]benzene + dithiothreitol disulfide + H2O	-	?
racemic 1-(methanesulfinyl)-4-methylbenzene + dithiothreitol	specifically reduces the (R)-enantiomer of methionine sulfoxide to methionine, 96.4% ee	Acidovorax sp. KKS102	1-methyl-4-(methylsulfanyl)benzene + 1-[(S)-methanesulfinyl]-4-methylbenzene + dithiothreitol disulfide + H2O	-	?

Synonyms

Synonyms	Comment	Organism
methionine sulfoxide reductase B	-	Acidovorax sp. KKS102
MsrB	-	Acidovorax sp. KKS102

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Release 2023.1 (January 2023)