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Literature summary for 1.8.4.12 extracted from

  • Zhao, C.; Hartke, A.; La Sorda, M.; Posteraro, B.; Laplace, J.M.; Auffray, Y.; Sanguinetti, M.
    Role of methionine sulfoxide reductases A and B of Enterococcus faecalis in oxidative stress and virulence (2010), Infect. Immun., 78, 3889-3897.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-methionine (R)-sulfoxide + thioredoxin Enterococcus faecalis
-
 L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine (R)-sulfoxide + thioredoxin Enterococcus faecalis JH2-2
-
 L-methionine + thioredoxin disulfide + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Enterococcus faecalis
-
-
-
Enterococcus faecalis JH2-2
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-methionine (R)-sulfoxide + thioredoxin
-
 Enterococcus faecalis L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine (R)-sulfoxide + thioredoxin
-
 Enterococcus faecalis JH2-2 L-methionine + thioredoxin disulfide + H2O
-
 ?

Synonyms

Synonyms Comment Organism
methionine sulfoxide reductase B
-
 Enterococcus faecalis
MsrB
-
 Enterococcus faecalis

General Information

General Information Comment Organism
malfunction deficiency in MsrB enzyme reduces the level of Enterococcus faecalis virulence in a systemic and urinary tract infection model Enterococcus faecalis
physiological function MsrB is important for the oxidative stress response, macrophage survival, and persistent infection with Enterococcus faecalis Enterococcus faecalis