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Literature summary for 1.8.4.12 extracted from

  • Cabreiro, F.; Picot, C.R.; Perichon, M.; Friguet, B.; Petropoulos, I.
    Overexpression of methionine sulfoxide reductases A and B2 protects MOLT-4 cells against zinc-induced oxidative stress (2009), Antioxid. Redox Signal., 11, 215-225.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
human MOLT-4 cell line are stably transfected with the pLXSN retroviral expression vector based on the Moloney murine leukemia virus and Moloney murine sarcoma virus to generate a replication-deficient recombinant retrovirus containing the rat MsrA and the human MsrB2 cDNA. The oxidized protein repair enzymes MsrA and MsrB2, when overexpressed in the cells, are able to counteract the zinc-mediated damaging effects Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y3D2
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Source Tissue

Source Tissue Comment Organism Textmining
MOLT-4 cell control and stably overexpressing MsrA (from rat) and MsrB2 (from human). Zinc treatment has a pro-antioxidant effect in MOLT-4 cells by positively modulating the activity of the Msr enzymes. Overexpression of the Msr enzymes, due to their antioxidant properties, counteracts the pro-oxidant effects of zinc treatment, which lead to a cellular protection against protein oxidative damage and cell death, by reducing the production of reactive oxygen species Homo sapiens
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Synonyms

Synonyms Comment Organism
methionine sulfoxide reductases B2
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Homo sapiens
MsrB
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Homo sapiens