Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | isozyme MsrB1 or selenoprotein R | Homo sapiens | 5829 | - |
endoplasmic reticulum | isozyme MsrB3 | Homo sapiens | 5783 | - |
mitochondrion | isozyme MsrB2 or CBS-1, and isozyme MsrB3 | Homo sapiens | 5739 | - |
nucleus | isozyme MsrB1 or selenoprotein R | Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-methionine-(R)-S-oxide + thioredoxin | Homo sapiens | stereospecific reduction, the isozymes of MsrB are involved in lens cell viability and oxidative stress protection | L-methionine + thioredoxin disulfide + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes MsrB1 or selenoprotein R, MsrB2 or CBS-1, and MsrB3 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone marrow | isozyme MsrB1 | Homo sapiens | - |
cerebellum | isozyme MsrB2 | Homo sapiens | - |
colon | isozymes MsrB3 and MsrB2 | Homo sapiens | - |
heart | isozymes MsrB3 and MsrB2 | Homo sapiens | - |
kidney | isozyme MsrB1 and MsrB2 | Homo sapiens | - |
lens | epithelia and fibers, isozymes MsrB1 or selenoprotein R, MsrB2 or CBS-1, and MsrB3, differential expression patterns of isozymes, overview | Homo sapiens | - |
additional information | tissue-specific expression of MsrB isozymes, overview | Homo sapiens | - |
skeletal muscle | isozymes MsrB1 and MsrB2 | Homo sapiens | - |
small intestine | isozyme MsrB3 | Homo sapiens | - |
spleen | isozyme MsrB1 | Homo sapiens | - |
SRA01/04 cell | i.e. HLE cell, transformed human lens epithelial cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-methionine-(R)-S-oxide + thioredoxin | stereospecific reduction | Homo sapiens | L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine-(R)-S-oxide + thioredoxin | stereospecific reduction, the isozymes of MsrB are involved in lens cell viability and oxidative stress protection | Homo sapiens | L-methionine + thioredoxin disulfide + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CBS-1 | - |
Homo sapiens |
methionine sulfoxide reductase B | - |
Homo sapiens |
MsrB | - |
Homo sapiens |
selenoprotein R | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
thioredoxin | - |
Homo sapiens |