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Literature summary for 1.8.4.11 extracted from

  • Arias, D.G.; Cabeza, M.S.; Echarren, M.L.; Faral-Tello, P.; Iglesias, A.A.; Robello, C.; Guerrero, S.A.
    On the functionality of a methionine sulfoxide reductase B from Trypanosoma cruzi (2020), Free Radic. Biol. Med., 158, 96-114 .
    View publication on PubMed
Search for more literature for 1.8.4.11

Cloned(Commentary)

Cloned (Comment) Organism
-
 Trypanosoma cruzi

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.006
-
 thioredoxin pH 7.5, 30°C, cosubstrate: L-methionine-(S)-S-oxide Trypanosoma cruzi
0.017
-
 tryparedoxin I pH 7.5, 30°C, cosubstrate: N-acetyl-L-methionine-(S)-S-oxide Trypanosoma cruzi
0.42
-
 L-methionine-(S)-S-oxide pH 7.5, 30°C, cosubstrate: tryparedoxin I Trypanosoma cruzi
0.86
-
 N-acetyl-L-methionine-(S)-S-oxide pH 7.5, 30°C, cosubstrate: tryparedoxin I Trypanosoma cruzi

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Trypanosoma cruzi 5829
-
mitochondrion
-
 Trypanosoma cruzi 5739
-

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi V5BTN0
-
-
Trypanosoma cruzi Dm28c V5BTN0
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-methionine-(S)-S-oxide + thioredoxin
-
 Trypanosoma cruzi L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine-(S)-S-oxide + thioredoxin
-
 Trypanosoma cruzi Dm28c L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine-(S)-S-oxide + tryparedoxin I
-
 Trypanosoma cruzi L-methionine + tryparedoxin I disulfide + H2O
-
 ?
L-methionine-(S)-S-oxide + tryparedoxin I
-
 Trypanosoma cruzi Dm28c L-methionine + tryparedoxin I disulfide + H2O
-
 ?
additional information no activity with glutathione Trypanosoma cruzi ?
-
-
additional information no activity with glutathione Trypanosoma cruzi Dm28c ?
-
-
N-acetyl-L-methionine-(S)-S-oxide + tryparedoxin I
-
 Trypanosoma cruzi N-acetyl-L-methionine + tryparedoxin I disulfide + H2O
-
 ?
N-acetyl-L-methionine-(S)-S-oxide + tryparedoxin I
-
 Trypanosoma cruzi Dm28c N-acetyl-L-methionine + tryparedoxin I disulfide + H2O
-
 ?

Synonyms

Synonyms Comment Organism
methionine sulfoxide reductase A
-
 Trypanosoma cruzi
MsrA
-
 Trypanosoma cruzi
TCDM_14270
-
 Trypanosoma cruzi

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.025
-
 thioredoxin pH 7.5, 30°C, cosubstrate: L-methionine-(S)-S-oxide Trypanosoma cruzi
0.22
-
 N-acetyl-L-methionine-(S)-S-oxide pH 7.5, 30°C, cosubstrate: tryparedoxin I Trypanosoma cruzi
0.23
-
 L-methionine-(S)-S-oxide pH 7.5, 30°C, cosubstrate: tryparedoxin I Trypanosoma cruzi
0.467
-
 tryparedoxin I pH 7.5, 30°C, cosubstrate: N-acetyl-L-methionine-(S)-S-oxide Trypanosoma cruzi

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.258
-
 N-acetyl-L-methionine-(S)-S-oxide pH 7.5, 30°C, cosubstrate: tryparedoxin I Trypanosoma cruzi
0.548
-
 L-methionine-(S)-S-oxide pH 7.5, 30°C, cosubstrate: tryparedoxin I Trypanosoma cruzi
4.167
-
 thioredoxin pH 7.5, 30°C, cosubstrate: L-methionine-(S)-S-oxide Trypanosoma cruzi
27.45
-
 tryparedoxin I pH 7.5, 30°C, cosubstrate: N-acetyl-L-methionine-(S)-S-oxide Trypanosoma cruzi