Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
PC-12 cell | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
methionine sulfoxide reductase | - |
Rattus norvegicus |
MSR | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | oxidative stress reduces the expression of the enzyme (MsrA) following treatment with 1-methyl-4-phenylpyridinium | down |
Rattus norvegicus | astragaloside IV protects PC-12 cells from 1-methyl-4-phenylpyridinium-induced oxidative damage through upregulating MsrA. MsrA expression is dependent on the Sirt1-FOXO3a signaling pathway | up |
General Information | Comment | Organism |
---|---|---|
drug target | astragaloside IV protects PC-12 cells from 1-methyl-4-phenylpyridinium-induced oxidative damage through upregulating MsrA. Astragaloside IV may serve as an effective therapeutic agent for aging and Parkinson's disease | Rattus norvegicus |
metabolism | MsrA expression is dependent on the Sirt1-FOXO3a signaling pathway | Rattus norvegicus |
physiological function | the enzyme repairs oxidatively damaged proteins through acting as an antioxidant | Rattus norvegicus |