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Literature summary for 1.8.4.11 extracted from

  • Liu, Y.; Chong, L.; Li, X.; Tang, P.; Liu, P.; Hou, C.; Zhang, X.; Li, R.
    Astragaloside IV rescues MPP+-induced mitochondrial dysfunction through upregulation of methionine sulfoxide reductase A (2017), Exp. Ther. Med., 14, 2650-2656 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
PC-12 cell
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Rattus norvegicus
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Synonyms

Synonyms Comment Organism
methionine sulfoxide reductase
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Rattus norvegicus
MSR
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Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus oxidative stress reduces the expression of the enzyme (MsrA) following treatment with 1-methyl-4-phenylpyridinium down
Rattus norvegicus astragaloside IV protects PC-12 cells from 1-methyl-4-phenylpyridinium-induced oxidative damage through upregulating MsrA. MsrA expression is dependent on the Sirt1-FOXO3a signaling pathway up

General Information

General Information Comment Organism
drug target astragaloside IV protects PC-12 cells from 1-methyl-4-phenylpyridinium-induced oxidative damage through upregulating MsrA. Astragaloside IV may serve as an effective therapeutic agent for aging and Parkinson's disease Rattus norvegicus
metabolism MsrA expression is dependent on the Sirt1-FOXO3a signaling pathway Rattus norvegicus
physiological function the enzyme repairs oxidatively damaged proteins through acting as an antioxidant Rattus norvegicus