Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9D6Y7 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
methionine sulfoxide reductase A | - |
Mus musculus |
MsrA | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | MsrA-/- mice are more susceptible to lipopolysaccharide (LPS) induced lethal shock than wild-type (MsrA+/+) mice. Serum levels of the proinflammatory cytokines IL-6 and TNF-alpha induced by LPS are higher in MsrA-/- than in MsrA+/+ mice. MsrA deficiency in the bone marrow-derived macrophages (BMDMs) also increases the LPS-induced cytotoxicity as well as TNF-alpha level. Basal and LPS-induced reactive oxygen species (ROS) levels are higher in MsrA-/- than in MsrA+/+ bone marrow-derived macrophages. Phosphorylation levels of p38, JNK, and ERK are higher in MsrA-/- than in MsrA+/+ BMDMs in response to LPS, suggesting that MsrA deficiency increases MAPK activation. MsrA deficiency increased the expression and nuclear translocation of NF-kappaB and the expression of inducible nitric oxide synthase, a target gene of NF-kappaB, in response to lipopolysaccharide (LPS) | Mus musculus |
physiological function | the enzyme (MsrA) protects against LPS-induced septic shock, and negatively regulates proinflammatory responses via inhibition of the ROS-MAPK-NF-kappaB signaling pathways | Mus musculus |