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Literature summary for 1.8.4.11 extracted from

  • Singh, M.P.; Kim, K.Y.; Kwak, G.H.; Baek, S.H.; Kim, H.Y.
    Methionine sulfoxide reductase A protects against lipopolysaccharide-induced septic shock via negative regulation of the proinflammatory responses (2017), Arch. Biochem. Biophys., 631, 42-48 .
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus Q9D6Y7
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-

Synonyms

Synonyms Comment Organism
methionine sulfoxide reductase A
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Mus musculus
MsrA
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Mus musculus

General Information

General Information Comment Organism
malfunction MsrA-/- mice are more susceptible to lipopolysaccharide (LPS) induced lethal shock than wild-type (MsrA+/+) mice. Serum levels of the proinflammatory cytokines IL-6 and TNF-alpha induced by LPS are higher in MsrA-/- than in MsrA+/+ mice. MsrA deficiency in the bone marrow-derived macrophages (BMDMs) also increases the LPS-induced cytotoxicity as well as TNF-alpha level. Basal and LPS-induced reactive oxygen species (ROS) levels are higher in MsrA-/- than in MsrA+/+ bone marrow-derived macrophages. Phosphorylation levels of p38, JNK, and ERK are higher in MsrA-/- than in MsrA+/+ BMDMs in response to LPS, suggesting that MsrA deficiency increases MAPK activation. MsrA deficiency increased the expression and nuclear translocation of NF-kappaB and the expression of inducible nitric oxide synthase, a target gene of NF-kappaB, in response to lipopolysaccharide (LPS) Mus musculus
physiological function the enzyme (MsrA) protects against LPS-induced septic shock, and negatively regulates proinflammatory responses via inhibition of the ROS-MAPK-NF-kappaB signaling pathways Mus musculus