Literature summary for 1.8.4.11 extracted from

Minniti, A.N.; Arrazola, M.S.; Bravo-Zehnder, M.; Ramos, F.; Inestrosa, N.C.; Aldunate, R.
The protein oxidation repair enzyme methionine sulfoxide reductase a modulates Abeta aggregation and toxicity in vivo (2015), Antioxid. Redox Signal., 22, 48-62 .

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Application

Application	Comment	Organism
medicine	Caenorhabditis elegans model of the human amyloidogenic disease inclusion body myositis. In a constitutive transgenic Abeta strain that lacks MSRA-1, the number of amyloid aggregates decreases while the number of oligomeric Abeta species increases. The results correlate with enhanced synaptic dysfunction and mislocalization of the nicotinic acetylcholine receptor ACR-16 at the neuromuscular junction	Caenorhabditis elegans

Organism

Organism	UniProt	Comment	Textmining
Caenorhabditis elegans	O02089	-	-

Synonyms

Synonyms	Comment	Organism
MSRA-1	-	Caenorhabditis elegans

General Information

General Information	Comment	Organism
physiological function	Caenorhabditis elegans model of the human amyloidogenic disease inclusion body myositis. In a constitutive transgenic Abeta strain that lacks MSRA-1, the number of amyloid aggregates decreases while the number of oligomeric Abeta species increases. The results correlate with enhanced synaptic dysfunction and mislocalization of the nicotinic acetylcholine receptor ACR-16 at the neuromuscular junction	Caenorhabditis elegans

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Release 2023.1 (January 2023)