Literature summary for 1.8.4.11 extracted from

Wassef, R.; Haenold, R.; Hansel, A.; Brot, N.; Heinemann, S.H.; Hoshi, T.
Methionine sulfoxide reductase A and a dietary supplement S-methyl-L-cysteine prevent Parkinsons-like symptoms (2007), J. Neurosci., 27, 12808-12816.

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Application

Application	Comment	Organism
medicine	interventions focusing on the enzymatic reduction of oxidized methionine catalyzed by MSRA represents a new prevention and therapeutic approach for Parkinsons disease and potentially for other neurodegenerative diseases involving oxidative stress	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
Drosophila line overexpresses both human alpha-synuclein and MSRA	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	MSRA inhibits development of the locomotor and circadian rhythm defects caused by ectopic expression of human alpha-synuclein in the Drosophila nervous system. One way to enhance the MSRA antioxidant system is dietary supplementation with S-methyl-L-cysteine, found abundantly in garlic, cabbage, and turnips. S-methyl-L-cysteine prevents the alpha-synuclein-induced abnormalities	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9UJ68	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	MSRA inhibits development of the locomotor and circadian rhythm defects caused by ectopic expression of human alpha-synuclein in the Drosophila nervous system. One way to enhance the MSRA antioxidant system is dietary supplementation with S-methyl-L-cysteine, found abundantly in garlic, cabbage, and turnips. S-methyl-L-cysteine prevents the alpha-synuclein-induced abnormalities	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
methionine sulfoxide reductase A	-	Homo sapiens
MsrA	-	Homo sapiens

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Release 2023.1 (January 2023)