BRENDA - Enzyme Database
show all sequences of 1.8.4.11

Elevated levels of brain-pathologies associated with neurodegenerative diseases in the methionine sulfoxide reductase A knockout mouse

Pal, R.; Oien, D.B.; Ersen, F.Y.; Moskovitz, J.; Exp. Brain Res. 180, 765-774 (2007)

Data extracted from this reference:

Organism
Organism
UniProt
Commentary
Textmining
Mus musculus
Q9D6Y7
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
a knockout mouse strain of the methionine sulfoxide reductase A gene (MsrA-/-) causes an enhanced neurodegeneration in brain hippocampus relative to its wild-type control mouse brain. Deficiency in MsrA activity fosters oxidative-stress that is manifested by the accumulation of faulty proteins (via methionine oxidation), deposition of aggregated proteins, and premature brain cell death
Mus musculus
-
Synonyms
Synonyms
Commentary
Organism
methionine sulfoxide reductase A
-
Mus musculus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
a knockout mouse strain of the methionine sulfoxide reductase A gene (MsrA-/-) causes an enhanced neurodegeneration in brain hippocampus relative to its wild-type control mouse brain. Deficiency in MsrA activity fosters oxidative-stress that is manifested by the accumulation of faulty proteins (via methionine oxidation), deposition of aggregated proteins, and premature brain cell death
Mus musculus
-
Other publictions for EC 1.8.4.11
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
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Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
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Temperature Stability [°C]
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Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)