Cloned (Comment) | Organism |
---|---|
gene msrA, subcloning in Escherichia coli, stable functional overexpression of MsrA in Saccharomyces cerevisiae and human T cells | Saccharomyces cerevisiae |
Protein Variants | Comment | Organism |
---|---|---|
additional information | overexpression of peptide-methionine sulfoxide reductase in Saccharomyces cerevisiae, resulting in a strain with 25fold increased activity, and Molt-4 human lymphocyte cells provides them with high resistance to oxidative stress by H2O2, paraquat, or 2,2'-azobis-(2-amidinopropane) dihydrochloride, the recombinant yeast strain grows better and and shows a higher survival rate compared to the wild-type parent strain | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Saccharomyces cerevisiae | MsrA protects the cell against damage caused by oxidative stress through treatment with H2O2, paraquat, or 2,2'-azobis-(2-amidinopropane) dihydrochloride | ? | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | Saccharomyces cerevisiae | - |
peptide-L-methionine + thioredoxin disulfide + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
gene msrA | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
cell survival rates after treatement with H2O2, paraquat, or 2,2'-azobis-(2-amidinopropane) dihydrochloride | Saccharomyces cerevisiae |
0.000015 | - |
wild-type Saccharomyces cerevisiae strain, substrate L-methionine-(S)-S-oxide | Saccharomyces cerevisiae |
0.000068 | - |
wild-type Saccharomyces cerevisiae strain, substrate dabsyl-L-methionine-(S)-S-oxide | Saccharomyces cerevisiae |
0.0003 | - |
recombinant Saccharomyces cerevisiae strain overexpressing MsrA, substrate L-methionine-(S)-S-oxide | Saccharomyces cerevisiae |
0.0017 | - |
recombinant Saccharomyces cerevisiae strain overexpressing MsrA, substrate dabsyl-L-methionine-(S)-S-oxide | Saccharomyces cerevisiae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dabsyl-L-methionine-(S)-S-oxide + thioredoxin | - |
Saccharomyces cerevisiae | dabsyl-L-methionine + thioredoxin disulfide + H2O | - |
? | |
L-methionine-(S)-S-oxide + thioredoxin | - |
Saccharomyces cerevisiae | L-methionine + thioredoxin disulfide + H2O | - |
? | |
additional information | MsrA protects the cell against damage caused by oxidative stress through treatment with H2O2, paraquat, or 2,2'-azobis-(2-amidinopropane) dihydrochloride | Saccharomyces cerevisiae | ? | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | - |
Saccharomyces cerevisiae | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MsrA | - |
Saccharomyces cerevisiae |
peptide-methionine sulfoxide reductase | - |
Saccharomyces cerevisiae |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Saccharomyces cerevisiae |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Saccharomyces cerevisiae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
thioredoxin | - |
Saccharomyces cerevisiae |