Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | H2O2 induces MsrA expression in a thioredoxin-dependent manner, msrA promoter and calcium phospholipid binding protein, CPBP, form a complex and enhance msrA expression, cytosolic thioredoxins 1 and 2 are involved in the regulation | Saccharomyces cerevisiae |
Cloned (Comment) | Organism |
---|---|
gene msrA, msrA promoter and calcium phopsholipid binding protein, CPBP, form a complex and enhance msrA expression in absence of presence of H2O2, cytosolic thioredoxins 1 and 2 are involved in the regulation, overview | Saccharomyces cerevisiae |
Protein Variants | Comment | Organism |
---|---|---|
additional information | thioredoxin-deficient yeast strains show increased sensitivity to H2O2 | Saccharomyces cerevisiae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
peptide-L-methionine-(S)-S-oxide + thioredoxin | Saccharomyces cerevisiae | MsrA regulation, overview | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | Saccharomyces cerevisiae BY4743 | MsrA regulation, overview | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
gene msrA | - |
Saccharomyces cerevisiae BY4743 | - |
gene msrA | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dabsyl-L-methionine-(S)-S-oxide + DTT | stereospecific reduction | Saccharomyces cerevisiae | dabsyl-L-methionine + DTT disulfide + H2O | - |
? | |
dabsyl-L-methionine-(S)-S-oxide + DTT | stereospecific reduction | Saccharomyces cerevisiae BY4743 | dabsyl-L-methionine + DTT disulfide + H2O | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | stereospecific reduction | Saccharomyces cerevisiae | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | MsrA regulation, overview | Saccharomyces cerevisiae | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | stereospecific reduction | Saccharomyces cerevisiae BY4743 | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? | |
peptide-L-methionine-(S)-S-oxide + thioredoxin | MsrA regulation, overview | Saccharomyces cerevisiae BY4743 | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
methionine sulfoxide reductase A | - |
Saccharomyces cerevisiae |
MsrA | - |
Saccharomyces cerevisiae |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Saccharomyces cerevisiae |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Saccharomyces cerevisiae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
thioredoxin | cytosolic thioredoxins 1 and 2 are involved in regulation of MsrA exression | Saccharomyces cerevisiae |