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Literature summary for 1.8.3.7 extracted from

  • Boschanski, M.; Krueger, T.; Karsten, L.; Falck, G.; Alam, S.; Gerlach, M.; Mueller, B.; Mueller, K.M.; Sewald, N.; Dierks, T.
    Site-specific conjugation strategy for dual antibody-drug conjugates using aerobic formylglycine-generating enzymes (2021), Bioconjug. Chem., 32, 1167-1174 .
    View publication on PubMed
Search for more literature for 1.8.3.7

Application

Application Comment Organism
biotechnology site-specific conjugation strategy for dual antibody-drug conjugates using aerobic formylglycine-generating enzymes Mycobacterium tuberculosis
biotechnology site-specific conjugation strategy for dual antibody-drug conjugates using aerobic formylglycine-generating enzymes Streptomyces coelicolor
biotechnology site-specific conjugation strategy for dual antibody-drug conjugates using aerobic formylglycine-generating enzymes Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Cu2+ the substrate specificity for the cysteine motifs CTPS is not changed upon addition of the cofactor copper Homo sapiens
Cu2+ Cu2+-treated enzyme converts both cysteine motifs (CTPSR and CTAGR) Mycobacterium tuberculosis
Cu2+ Cu2+-treated enzyme converts both cysteine motifs (CTPSR and CTAGR) Streptomyces coelicolor

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8NBK3
-
-
Mycobacterium tuberculosis
-
-
-
Streptomyces coelicolor
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ac-EQSCTAGRAAFITGQGLCTPSRAG-NH2 + O2 + a thiol accepts the sequence CTPSR. The human enzyme strictly convertes proline-containing aldehyde tags, either in vivo or in vitro, whereas in the presence of copper, the enzyme fom Streptomyces coelicolor and Mycobacterium tuberculosis tolerate proline-to-alanine substitutions in the core motif Mycobacterium tuberculosis ?
-
 ?
Ac-EQSCTAGRAAFITGQGLCTPSRAG-NH2 + O2 + a thiol accepts the sequence CTPSR. The human enzyme strictly convertes proline-containing aldehyde tags, either in vivo or in vitro, whereas in the presence of copper, the enzyme fom Streptomyces coelicolor and Mycobacterium tuberculosis tolerate proline-to-alanine substitutions in the core motif Streptomyces coelicolor ?
-
 ?
Ac-EQSCTAGRAAFITGQGLCTPSRAG-NH2 + O2 + reduced dithiothreitol accepts the sequence CTPSR. The human enzyme strictly converts proline-containing aldehyde tags, either in vivo or in vitro, whereas in the presence of copper, the enzyme fom Streptomyces coelicolor and Mycobacterium tuberculosis tolerate proline-to-alanine substitutions in the core motif Homo sapiens ? + hydrogen sulfide + oxidized dithiothreitol + H2O
-
 ?

Synonyms

Synonyms Comment Organism
FGE
-
 Mycobacterium tuberculosis
FGE
-
 Streptomyces coelicolor
FGE
-
 Homo sapiens