Literature summary for 1.8.3.2 extracted from

Zheng, W.; Liu, F.; Du, F.; Yang, F.; Kou, X.; He, Y.; Feng, H.; Fan, Q.; Luo, E.; Min, H.; Miao, J.; Cui, L.; Cao, Y.
Characterization of a sulfhydryl oxidase from Plasmodium berghei as a target for blocking parasite transmission (2020), Front. Cell. Infect. Microbiol., 10, 311 .

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Plasmodium berghei

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Plasmodium berghei	5737	-
plasma membrane	of gametes and ookinetes	Plasmodium berghei	5886	-

Organism

Organism	UniProt	Comment	Textmining
Plasmodium berghei	-	-	-
Plasmodium berghei ANKA 2.34	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Plasmodium berghei

Source Tissue

Source Tissue	Comment	Organism	Textmining
gametocyte	-	Plasmodium berghei	-
germ cell	-	Plasmodium berghei	-
additional information	not expressed in asexual erythrocytic stages	Plasmodium berghei	-
ookinete	-	Plasmodium berghei	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2 dithiothreitol + O2	-	Plasmodium berghei	dithiothreitol disulfide + H2O2	-	?
2 dithiothreitol + O2	-	Plasmodium berghei ANKA 2.34	dithiothreitol disulfide + H2O2	-	?

Synonyms

Synonyms	Comment	Organism
QSOX	-	Plasmodium berghei
quiescin sulfhydryl oxidase	-	Plasmodium berghei

General Information

General Information	Comment	Organism
drug target	QSOX is a potential target for blocking parasite transmission	Plasmodium berghei
malfunction	Pbqsox deletion (DELTApbqsox) does not affect asexual intraerythrocytic development, but reduces exflagellation of male gametocytes as well as formation and maturation of ookinetes. Pbqsox deletion also leads to a significant increase in the reduced thiol groups of ookinete surface proteins	Plasmodium berghei
physiological function	the enzyme catalyzes the insertion of disulfide bonds into unfolded, reduced proteins. It is required for parasite sexual development especially for ookinete maturation	Plasmodium berghei

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Release 2023.1 (January 2023)