Literature summary for 1.8.3.2 extracted from

Soloviev, M.; Esteves, M.P.; Amiri, F.; Crompton, M.R.; Rider, C.C.
Elevated transcription of the gene QSOX1 encoding quiescin Q6 sulfhydryl oxidase 1 in breast cancer (2013), PLoS ONE, 8, e57327 .

Application

Application	Comment	Organism
diagnostics	QSOX1 is a potential prognostic marker which may prove of use in the staging of breast tumours and the stratification of breast cancer patients	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
gene QSOX1, DNA and amino acid sequence determination and analysis, quantitative real-time PCR enzyme expression analysis, two putative alternative splicing variants might contribute to the differences in expression level between exon 7 and the 3'UTR are QSOX1d and QSOX1e. In QSOX1d the thioredoxin TRX1 domain remains intact, whilst the TRX2 and HRR domains are removed completely, making these isoforms similar to plant QSOXs which lack the second Trx domain but have the same three redox sites. TRX1 is truncated at its C-terminus in QSOX1e and both of the splicing	Homo sapiens

Cloned (Comment)

Organism

gene QSOX1, DNA and amino acid sequence determination and analysis, quantitative real-time PCR enzyme expression analysis, two putative alternative splicing variants might contribute to the differences in expression level between exon 7 and the 3'UTR are QSOX1d and QSOX1e. In QSOX1d the thioredoxin TRX1 domain remains intact, whilst the TRX2 and HRR domains are removed completely, making these isoforms similar to plant QSOXs which lack the second Trx domain but have the same three redox sites. TRX1 is truncated at its C-terminus in QSOX1e and both of the splicing

Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O00391	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast cancer cell	expression analysis of a panel of cDNAs derived from 50 clinically-graded normal and malignant breast tissue samples for the expression of QSOX1 mRNAs, significant correlation between relative transcript level and clinical grade malignant breast tumors	Homo sapiens	-
T-47D cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
QSOx1	-	Homo sapiens
quiescin Q6 sulfhydryl oxidase 1	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
FAD	-	Homo sapiens

General Information

General Information	Comment	Organism
evolution	the enzyme belongs to a family of flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidases	Homo sapiens