Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.8.1.B1 extracted from

  • Guevara-Flores, A.; Martinez-Gonzalez, J.J.; Herrera-Juarez, A.M.; Rendon, J.L.; Gonzalez-Andrade, M.; Torres Duran, P.V.; Enriquez-Habib, R.G.; Del Arenal Mena, I.P.
    Effect of curcuminoids and curcumin derivate products on thioredoxin-glutathione reductase from Taenia crassiceps cysticerci. Evidence suggesting a curcumin oxidation product as a suitable inhibitor (2019), PLoS ONE, 14, e0220098 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.8.1.B1

Inhibitors

Inhibitors Comment Organism Structure
4-vinylguaiacol
-
 Taenia crassiceps
bis-demethoxycurcumin inhibits in the micromolar concentration range Taenia crassiceps
curcumin time-dependent process. An intermediary compound of curcumin oxidation, probably spiroepoxide, is responsible. Preincubation of curcumin in the presence of NADPH results in the loss of its inhibitory ability. Preincubation of curcumin with sulfhydryl compounds fully protected the enzyme from inhibition Taenia crassiceps
demethoxycurcumin inhibits in the micromolar concentration range Taenia crassiceps
ferulic acid
-
 Taenia crassiceps
ferulic aldehyde
-
 Taenia crassiceps
feruloylmethane
-
 Taenia crassiceps
vanillic acid
-
 Taenia crassiceps
Vanillin
-
 Taenia crassiceps

Organism

Organism UniProt Comment Textmining
Taenia crassiceps
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cysticercus
-
 Taenia crassiceps
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione disulfide + NADPH + H+
-
 Taenia crassiceps 2 glutathione + NADP+
-
 ?
thioredoxin disulfide + NADPH + H+
-
 Taenia crassiceps thioredoxin + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
TGR
-
 Taenia crassiceps
thioredoxin glutathione reductase
-
 Taenia crassiceps

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0129
-
 25°C, pH not specified in the publication Taenia crassiceps 4-vinylguaiacol
0.122
-
 25°C, pH not specified in the publication Taenia crassiceps feruloylmethane
0.127
-
 25°C, pH not specified in the publication Taenia crassiceps Vanillin
0.18
-
 25°C, pH not specified in the publication Taenia crassiceps ferulic aldehyde
0.465
-
 25°C, pH not specified in the publication Taenia crassiceps ferulic acid
0.657
-
 25°C, pH not specified in the publication Taenia crassiceps vanillic acid