Application | Comment | Organism |
---|---|---|
medicine | quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade, several of which are highly potent and should serve both as mechanistic tools for probing the redox balance in Schistosome mansoni, and starting points for developing medicinal leads for treatments for schistosomiasis | Schistosoma mansoni |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2-oxido-1,2,5-oxadiazole-3,4-diyl)bis(2-furylmethanone) | - |
Schistosoma mansoni | |
(2-oxido-1,2,5-oxadiazole-3,4-diyl)bis(2-thienylmethanone) | - |
Schistosoma mansoni | |
(2-oxido-1,2,5-oxadiazole-3,4-diyl)bis[(1,3-dimethyl-1H-pyrazol-4-yl)methanone] | - |
Schistosoma mansoni | |
(2-oxido-1,2,5-oxadiazole-3,4-diyl)bis[(4-methoxyphenyl)methanone] | - |
Schistosoma mansoni | |
2-(4-chlorophenoxy)-6-methyl-2,3-dihydro-1,3,2-diazaphosphinin-4(1H)-one 2-oxide | - |
Schistosoma mansoni | |
2-(4-ethoxyphenoxy)-6-methyl-2,3-dihydro-1,3,2-diazaphosphinin-4(1H)-one 2-oxide | - |
Schistosoma mansoni | |
3-bromo-5-butoxy-6H-anthra[1,9-cd]isoxazol-6-one | - |
Schistosoma mansoni | |
4-phenyl-1,2,5-oxadiazole-3-carbonitrile 2-oxide | - |
Schistosoma mansoni | |
6-methyl-2-phenoxy-2,3-dihydro-1,3,2-diazaphosphinin-4(1H)-one 2-oxide | - |
Schistosoma mansoni | |
diethyl (3-bromo-6-oxo-6H-anthra[1,9-cd]isoxazol-5-yl)propanedioate | - |
Schistosoma mansoni | |
dimethyl (3-bromo-6-oxo-6H-anthra[1,9-cd]isoxazol-5-yl)propanedioate | - |
Schistosoma mansoni | |
P-1,3-benzothiazol-2-yl-N-(2-fluorophenyl)-P-phenylphosphinic amide | - |
Schistosoma mansoni | |
P-1,3-benzothiazol-2-yl-N-(5-chloropyridin-2-yl)-P-phenylphosphinic amide | - |
Schistosoma mansoni | |
P-1,3-benzothiazol-2-yl-P-phenyl-N-1,3-thiazol-2-ylphosphinic amide | - |
Schistosoma mansoni |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Schistosoma mansoni | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+ | - |
Schistosoma mansoni | 2-nitro-5-thiobenzoate + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TGR | - |
Schistosoma mansoni |
thioredoxin/glutathione reductase | - |
Schistosoma mansoni |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00002 | - |
- |
Schistosoma mansoni | (2-oxido-1,2,5-oxadiazole-3,4-diyl)bis(2-thienylmethanone) | |
0.000025 | - |
- |
Schistosoma mansoni | (2-oxido-1,2,5-oxadiazole-3,4-diyl)bis(2-furylmethanone) | |
0.000025 | - |
- |
Schistosoma mansoni | P-1,3-benzothiazol-2-yl-P-phenyl-N-1,3-thiazol-2-ylphosphinic amide | |
0.00006 | - |
- |
Schistosoma mansoni | (2-oxido-1,2,5-oxadiazole-3,4-diyl)bis[(4-methoxyphenyl)methanone] | |
0.00008 | - |
- |
Schistosoma mansoni | dimethyl (3-bromo-6-oxo-6H-anthra[1,9-cd]isoxazol-5-yl)propanedioate | |
0.00015 | - |
- |
Schistosoma mansoni | 3-bromo-5-butoxy-6H-anthra[1,9-cd]isoxazol-6-one | |
0.00055 | - |
- |
Schistosoma mansoni | 2-(4-chlorophenoxy)-6-methyl-2,3-dihydro-1,3,2-diazaphosphinin-4(1H)-one 2-oxide | |
0.0006 | - |
- |
Schistosoma mansoni | 2-(4-ethoxyphenoxy)-6-methyl-2,3-dihydro-1,3,2-diazaphosphinin-4(1H)-one 2-oxide | |
0.0008 | - |
- |
Schistosoma mansoni | P-1,3-benzothiazol-2-yl-N-(5-chloropyridin-2-yl)-P-phenylphosphinic amide | |
0.0018 | - |
- |
Schistosoma mansoni | 4-phenyl-1,2,5-oxadiazole-3-carbonitrile 2-oxide | |
0.002 | - |
- |
Schistosoma mansoni | (2-oxido-1,2,5-oxadiazole-3,4-diyl)bis[(1,3-dimethyl-1H-pyrazol-4-yl)methanone] | |
0.004 | - |
- |
Schistosoma mansoni | 6-methyl-2-phenoxy-2,3-dihydro-1,3,2-diazaphosphinin-4(1H)-one 2-oxide | |
0.009 | - |
- |
Schistosoma mansoni | diethyl (3-bromo-6-oxo-6H-anthra[1,9-cd]isoxazol-5-yl)propanedioate | |
0.012 | - |
- |
Schistosoma mansoni | P-1,3-benzothiazol-2-yl-N-(2-fluorophenyl)-P-phenylphosphinic amide |