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Literature summary for 1.8.1.9 extracted from

  • Kapoor, G.; Banyal, H.S.
    Glutathione reductase and thioredoxin reductase: novel antioxidant enzymes from Plasmodium berghei (2009), Korean J. Parasitol., 47, 421-424.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.8.1.9

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Plasmodium berghei 5829
-

Organism

Organism UniProt Comment Textmining
Plasmodium berghei
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
-
 Plasmodium berghei 2-nitro-5-thiobenzoate + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
thioredoxin reductase
-
 Plasmodium berghei
TrxR
-
 Plasmodium berghei

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Plasmodium berghei

Expression

Organism Comment Expression
Plasmodium berghei activities of thioredoxin reductase in Plasmodium berghei-infected erythrocytes are higher than those in normal host cells up

General Information

General Information Comment Organism
malfunction TrxR knocked out parasites are non-viable Plasmodium berghei
physiological function TrxR helps maintenance of redox homeostasis in Plasmodium infection. TrxR is essential for the survival of erythrocytic stages of parasites Plasmodium berghei