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Literature summary for 1.8.1.9 extracted from

  • Mandal, P.K.; Seiler, A.; Perisic, T.; Koelle, P.; Banjac Canak, A.; Foerster, H.; Weiss, N.; Kremmer, E.; Lieberman, M.W.; Bannai, S.; Kuhlencordt, P.; Sato, H.; Bornkamm, G.W.; Conrad, M.
    System x(c)- and thioredoxin reductase 1 cooperatively rescue glutathione deficiency (2010), J. Biol. Chem., 285, 22244-22253.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.8.1.9

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol isoform Txnrd1 Rattus norvegicus 5829
-
mitochondrion isoform Txnrd2 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
thioredoxin disulfide + NADPH + H+ Rattus norvegicus
-
 thioredoxin + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thioredoxin disulfide + NADPH + H+
-
 Rattus norvegicus thioredoxin + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
thioredoxin reductase 1
-
 Rattus norvegicus
Txnrd1 isoform Rattus norvegicus
Txnrd2 isoform Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Rattus norvegicus
NADPH
-
 Rattus norvegicus

General Information

General Information Comment Organism
malfunction Txnrd1 knock-out cells cannot be rescued from glutathione depletion-induced cell death either by antioxidants, xCT overexpression, or co-culturing with xCT-overexpressing cells that condition the medium with Cys Rattus norvegicus
physiological function glutathione deficiency can be rescued by forced expression of xCT (the substrate-specific subunit of the cystine/glutamate antiporter), which additionally requires the presence of functional isoform Txnrd1, but not isoform Txnrd2 Rattus norvegicus