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Literature summary for 1.8.1.9 extracted from
- Mammalian thioredoxin reductase 1: roles in redox homoeostasis and characterization of cellular targets (2010), Biochem. J., 430, 285-293.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli BL21(DE3) cells | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | isoform TR1 | Mus musculus | 5829 | - |
| cytosol | isoform TR1 | Homo sapiens | 5829 | - |
| cytosol | isoform TR1 | Rattus norvegicus | 5829 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| selenium | selenoprotein | Mus musculus |  |
| selenium | selenoprotein | Homo sapiens | |
| selenium | selenoprotein | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 55000 | - |
isoform TR1, SDS-PAGE | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q16881 | isoform TR1 | - |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | O89049 | isoform TR1 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Ni-Sepharose column chromatography | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| liver | - |
Mus musculus | - |
| liver | - |
Rattus norvegicus | - |
| NIH-3T3 cell | - |
Mus musculus | - |
| serum | - |
Mus musculus | - |
| serum | - |
Rattus norvegicus | - |
| testis | isoform TR3 | Mus musculus | - |
| testis | isoform TR3 | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thioredoxin disulfide + NADPH + H+ | - |
Mus musculus | thioredoxin + NADP+ | - |
? | |
| thioredoxin disulfide + NADPH + H+ | - |
Homo sapiens | thioredoxin + NADP+ | - |
? | |
| thioredoxin disulfide + NADPH + H+ | - |
Rattus norvegicus | thioredoxin + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| thioredoxin reductase | - |
Mus musculus |
| thioredoxin reductase | - |
Homo sapiens |
| thioredoxin reductase | - |
Rattus norvegicus |
| TR1 | isoform | Mus musculus |
| TR1 | isoform | Homo sapiens |
| TR1 | isoform | Rattus norvegicus |
| TR3 | testes-specific isoform | Mus musculus |
| TR3 | testes-specific isoform | Homo sapiens |
| TR3 | testes-specific isoform | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Mus musculus | |
| FAD | - |
Homo sapiens | |
| FAD | - |
Rattus norvegicus | |
| NADPH | - |
Mus musculus | |
| NADPH | - |
Homo sapiens | |
| NADPH | - |
Rattus norvegicus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | cells deficient in isoformTR1 are particularly sensitive to diamide, while isoform TR3-knockdown cells are more sensitive to hydrogen peroxide | Mus musculus |
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Release 2023.1 (January 2023)
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