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Literature summary for 1.8.1.9 extracted from

  • Volonte, D.; Galbiati, F.
    Inhibition of thioredoxin reductase 1 by caveolin 1 promotes stress-induced premature senescence (2009), EMBO Rep., 10, 1334-1340.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.8.1.9

Inhibitors

Inhibitors Comment Organism Structure
calveolin overexpression of caveolin 1 inhibits TrxR activity by about 50% whereas a lack of caveolin 1 activates TrxR, both in vitro and in vivo Homo sapiens
calveolin overexpression of caveolin 1 inhibits TrxR activity by about 50% whereas a lack of caveolin 1 activates TrxR, both in vitro and in vivo Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane calveolar membrane Mus musculus 16020
-
membrane calveolar membrane Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16881
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell
-
 Homo sapiens
-
NIH-3T3 cell
-
 Mus musculus
-
WI-38 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thioredoxin disulfide + insulin
-
 Mus musculus thioredoxin + insulin disulfide
-
 ?
thioredoxin disulfide + NADPH + H+
-
 Mus musculus thioredoxin + NADP+
-
 ?
thioredoxin disulfide + NADPH + H+
-
 Homo sapiens thioredoxin + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
thioredoxin reductase 1
-
 Mus musculus
thioredoxin reductase 1
-
 Homo sapiens
TrxR1
-
 Mus musculus
TrxR1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Mus musculus
NADPH
-
 Homo sapiens